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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by mattdds on January 11, 2004, at 6:41:29
Well,
First of all, thanks for taking the time to answer my questions and orient this newb to Nardil. I know it takes time and effort. I appreciate that.
Stats:
Days taken: 5
Nardil 30 mg, first 2 days
Nardil 45 mg, next 3 daysHypertensive crises / episodes: 0
Benefits: Improved sleep
Side effects: odd dreamsI'm at day five now on Nardil. So far so good, no orthostatic hypotension problems, BP problems, no sexual problems, and really all around no side-effects at all. Seems pretty easy so far, but I know some of the side effects emerge later in treatment.
Only have noticed two things. First, better sleep, my sleep / wake pattern has normalized for the first time in years. This is pretty significant for me. I actually get tired when I'm supposed to and wake up at 6:30 AM every day!
The other thing, crazy dreams! Not necessarily scary, but heavy. I think this is the opposite that's supposed to happen. AD's in general usually reduce dreaming, right?
Anyway, I hope the SE profile stays this benign, because this seems to have promise!
Best,
Matt
Posted by SLS on January 11, 2004, at 10:21:36
In reply to Nardil Newbie Update (ACE), posted by mattdds on January 11, 2004, at 6:41:29
> I'm at day five now on Nardil. So far so good, no orthostatic hypotension problems, BP problems, no sexual problems, and really all around no side-effects at all.Some of these things don't appear until you are into your second week or reach 60mg, so be prepared. No reason to be scared, though. I wish you luck.
- Scott
Posted by Patient on January 11, 2004, at 11:06:12
In reply to Nardil Newbie Update (ACE), posted by mattdds on January 11, 2004, at 6:41:29
http://www.socialfear.com/nardil_increases_brain_gaba.html
The above link is very informative on how Nardil acts on the brain. The other link at that page, socialfear.com is also very informative about Nardil. The improved sleep is probably from GABA increase, and maybe effects on 5-HT2 receptors.
The best to you.
Posted by mattdds on January 11, 2004, at 16:40:45
In reply to Re: Nardil Newbie Update (ACE), posted by SLS on January 11, 2004, at 10:21:36
Scott,
Hey, thanks for your response!
>>Some of these things don't appear until you are into your second week or reach 60mg, so be prepared. No reason to be scared, though. I wish you luck.
I am gathering that 60 mg is considered by many to be the minimum therapeutic dose. Is this roughly correct?
Interesting that that is when all the side effects kick in as well, bummer.
Thanks,
Matt
Posted by mattdds on January 11, 2004, at 16:42:15
In reply to Re: Nardil +GABA, posted by Patient on January 11, 2004, at 11:06:12
Posted by SLS on January 11, 2004, at 17:14:33
In reply to Re: Nardil Newbie Update (ACE) » SLS, posted by mattdds on January 11, 2004, at 16:40:45
> >Some of these things don't appear until you are into your second week or reach 60mg, so be prepared. No reason to be scared, though. I wish you luck.
> I am gathering that 60 mg is considered by many to be the minimum therapeutic dose. Is this roughly correct?I would say yes.
> Interesting that that is when all the side effects kick in as well, bummer.
Yup. In fact, I knew a doctor who would measure the drop in blood pressure that occurs upon orthostatic challenge (standing up from a seated position), and use it as an indicator of adequate dosing. I don't recall what his criterion was.
- Scott
Posted by mattdds on January 11, 2004, at 18:04:41
In reply to Re: Nardil Newbie Update (ACE) » mattdds, posted by SLS on January 11, 2004, at 17:14:33
Scott,
Are you taking Nardil right now? If so, what dose?
How is it working, and for what indication?
Thanks again!
Matt
Posted by SLS on January 11, 2004, at 20:12:36
In reply to Re: Nardil Newbie Update » SLS, posted by mattdds on January 11, 2004, at 18:04:41
> Are you taking Nardil right now? If so, what dose?
No. However, I have taken it several times for periods up to 1 1/2 years. Unfortunately, I am only a partial responder to it. The best dosage for me was 75mg. I have been diagnosed as having bipolar depression with medication-induced manias (dysphoric). I am able to combine it with desipramine, but not imipramine. I experienced serotonin syndrome with imipramine. You should *never* combine any drug that is a serotonin uptake inhibitor with Nardil or Parnate.
How are you coming along?
- Scott
Posted by ace on January 13, 2004, at 23:09:58
In reply to Nardil Newbie Update (ACE), posted by mattdds on January 11, 2004, at 6:41:29
> Well,
>
> First of all, thanks for taking the time to answer my questions and orient this newb to Nardil. I know it takes time and effort. I appreciate that.
>
> Stats:
>
> Days taken: 5
> Nardil 30 mg, first 2 days
> Nardil 45 mg, next 3 days
>
> Hypertensive crises / episodes: 0
> Benefits: Improved sleepNardil is great for its sedative effect for me!
> Side effects: odd dreams
>
> I'm at day five now on Nardil. So far so good, no orthostatic hypotension problems, BP problems, no sexual problems, and really all around no side-effects at all. Seems pretty easy so far, but I know some of the side effects emerge later in treatment.Yes and no.
>
> Only have noticed two things. First, better sleep, my sleep / wake pattern has normalized for the first time in years. This is pretty significant for me. I actually get tired when I'm supposed to and wake up at 6:30 AM every day!
>
> The other thing, crazy dreams! Not necessarily scary, but heavy. I think this is the opposite that's supposed to happen. AD's in general usually reduce dreaming, right?In a couple weeks time REM sleep will be completely abolished. You MAY find yourself waking up at 4am and then going back to sleep./
> Anyway, I hope the SE profile stays this benign, because this seems to have promise!
>
> Best,
>
> MattKEEP IT UP CHAMP!!!
Ace.
This is the end of the thread.
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