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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by avid abulia on June 15, 2003, at 16:13:10
methylcobabalamin is the naturally-occurring metabolite of vitamin B12 that has neurological effects. it is, however, difficult to cause the liver to produce enough of it for orthomolecular treatment of neurological ailments. it must be taken sublingually to be effective.
it is, however, sold in japan as a neurology drug, and it is very cheap to import to the united states. i have recently acquired some, and i notice that it helps clear my thinking which is otherwise clouded by keppra, and i think i am starting to notice other, so far subtle, changes in mood, cognition, and seizure frequency.
does anyone have any experiences, positive or negative, with this compound?
~AA
Posted by linkadge on June 15, 2003, at 18:06:30
In reply to does anyone have any methylcobalamin experiences? , posted by avid abulia on June 15, 2003, at 16:13:10
I have not. I do take Vitamin B12 which has a distinct motivating and alerting effect for me.
Linkadge
Posted by Larry Hoover on June 15, 2003, at 18:52:10
In reply to does anyone have any methylcobalamin experiences? , posted by avid abulia on June 15, 2003, at 16:13:10
> methylcobabalamin is the naturally-occurring metabolite of vitamin B12 that has neurological effects. it is, however, difficult to cause the liver to produce enough of it for orthomolecular treatment of neurological ailments. it must be taken sublingually to be effective.
If you ensure adequate supply of glutathione, you'll maximize the decyanation reaction that is the rate-limiting step in the conversion of cyanocobalamin to methylcobalamin.
> it is, however, sold in japan as a neurology drug, and it is very cheap to import to the united states. i have recently acquired some, and i notice that it helps clear my thinking which is otherwise clouded by keppra, and i think i am starting to notice other, so far subtle, changes in mood, cognition, and seizure frequency.
>
> does anyone have any experiences, positive or negative, with this compound?
>
> ~AAI've never used methylcobalamin. I find good results from gram doses of cyanocobalamin. The neat thing is that B-12 absorption from food depends in part on existing B-12 stores, so cyancocabalamin intake will promote the uptake of natural forms like adenosylcobalamin and methylcobalamin from foodstuffs over time.
Lar
Posted by avid abulia on June 15, 2003, at 23:45:26
In reply to Re: does anyone have any methylcobalamin experiences? » avid abulia, posted by Larry Hoover on June 15, 2003, at 18:52:10
>
> If you ensure adequate supply of glutathione, you'll maximize the decyanation reaction that is the rate-limiting step in the conversion of cyanocobalamin to methylcobalamin.
>
> I've never used methylcobalamin. I find good results from gram doses of cyanocobalamin. The neat thing is that B-12 absorption from food depends in part on existing B-12 stores, so cyancocabalamin intake will promote the uptake of natural forms like adenosylcobalamin and methylcobalamin from foodstuffs over time.
>
> Lar
thanks larry, that is good info... i did not know that you could take gram-sized doses of B12, though... are you sure you are not thinking of milligram-sized doses (i.e. 1000mcg)? my current intake is at 3mg (3000mcg) of cyanocobabalamin, and 5mg (5000mcg) of methylcobalamin, and i notice a rather significant difference with the addition of methylcobalimin not obtained by raising doses of cyanocobalamin. i have a pretty good intake of glutathione as well as n-acetyl-cysteine (1000mg and 600mg respectively) above and beyond that obtained in my (though otherwise very nutrient-dense) anorexic diet... ugh, ana sucks, why can`t it by just a female disease like everyone seems to think any way?!not that i wish it on anyone, i just wish it off of me.
~AA
Posted by Larry Hoover on June 16, 2003, at 7:31:38
In reply to Re: does anyone have any methylcobalamin experiences?, posted by avid abulia on June 15, 2003, at 23:45:26
> >
> > If you ensure adequate supply of glutathione, you'll maximize the decyanation reaction that is the rate-limiting step in the conversion of cyanocobalamin to methylcobalamin.
> >
> > I've never used methylcobalamin. I find good results from gram doses of cyanocobalamin. The neat thing is that B-12 absorption from food depends in part on existing B-12 stores, so cyancocabalamin intake will promote the uptake of natural forms like adenosylcobalamin and methylcobalamin from foodstuffs over time.
> >
> > Lar
>
>
> thanks larry, that is good info... i did not know that you could take gram-sized doses of B12, though... are you sure you are not thinking of milligram-sized doses (i.e. 1000mcg)?Did I say gram? OOOOPPS. Miligram is what I meant.
Lar
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