Posted by Larry Hoover on June 15, 2003, at 18:52:10
In reply to does anyone have any methylcobalamin experiences? , posted by avid abulia on June 15, 2003, at 16:13:10
> methylcobabalamin is the naturally-occurring metabolite of vitamin B12 that has neurological effects. it is, however, difficult to cause the liver to produce enough of it for orthomolecular treatment of neurological ailments. it must be taken sublingually to be effective.
If you ensure adequate supply of glutathione, you'll maximize the decyanation reaction that is the rate-limiting step in the conversion of cyanocobalamin to methylcobalamin.
> it is, however, sold in japan as a neurology drug, and it is very cheap to import to the united states. i have recently acquired some, and i notice that it helps clear my thinking which is otherwise clouded by keppra, and i think i am starting to notice other, so far subtle, changes in mood, cognition, and seizure frequency.
>
> does anyone have any experiences, positive or negative, with this compound?
>
> ~AAI've never used methylcobalamin. I find good results from gram doses of cyanocobalamin. The neat thing is that B-12 absorption from food depends in part on existing B-12 stores, so cyancocabalamin intake will promote the uptake of natural forms like adenosylcobalamin and methylcobalamin from foodstuffs over time.
Lar
poster:Larry Hoover
thread:234149
URL: http://www.dr-bob.org/babble/20030614/msgs/234187.html