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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by deak on April 2, 2003, at 21:50:29
i see it is dopamine & norepinephrine agonist but please tell DOES IT AFFECT SEROTONIN LIKE NARDIL DOES? I THINK SO, BUT NOT SURE. PLEASE ANSWER PEOPLE.
HAPPY DAY,
Posted by Caleb462 on April 2, 2003, at 23:07:16
In reply to Parnate - is it serotonin agonist, posted by deak on April 2, 2003, at 21:54:01
> i see it is dopamine & norepinephrine agonist but please tell DOES IT AFFECT SEROTONIN LIKE NARDIL DOES? I THINK SO, BUT NOT SURE. PLEASE ANSWER PEOPLE.
>
> HAPPY DAY,
Yes, it does raise serotonin levels by inhibiting MAO-A. However, it is not a serotonin agonist. A serotonin agonist would be a drug that directly activates 5-HT receptors.
Posted by deak on April 2, 2003, at 23:30:03
In reply to Re: Parnate - is it serotonin agonist, posted by Caleb462 on April 2, 2003, at 23:07:16
Posted by JackD on April 3, 2003, at 14:13:20
In reply to Parnate - is it serotonin agonist, posted by deak on April 2, 2003, at 21:50:29
YES! It ihibits the Monoamine oxidace that oxidizes the amino acids serotonin, norepinephrine, and to a smaller extent dopamine. It is NOT an agonist, that is the wrong terminology. An agonist is like Cocaine, for example, which directly mimics dopamine and is therefore a D1 (dopamine suptype 1) agonist cause it stimulates it DIRECTLY. MAOI's don't directly stimulate anything, they just allow your neurotransmitter levels to rise.
Posted by Caleb462 on April 3, 2003, at 22:02:39
In reply to Re: Parnate - is it serotonin agonist, posted by JackD on April 3, 2003, at 14:13:20
> YES! It ihibits the Monoamine oxidace that oxidizes the amino acids serotonin, norepinephrine, and to a smaller extent dopamine. It is NOT an agonist, that is the wrong terminology. An agonist is like Cocaine, for example, which directly mimics dopamine and is therefore a D1 (dopamine suptype 1) agonist cause it stimulates it DIRECTLY. MAOI's don't directly stimulate anything, they just allow your neurotransmitter levels to rise.
Well, you are also mistaken. Cocaine is not a D1 agonist. It is a reuptake inhibitor of Dopamine, Norepinephrine, and Serotonin.
Posted by djmmm on April 5, 2003, at 18:07:14
In reply to Re: Parnate - is it serotonin agonist, posted by Caleb462 on April 3, 2003, at 22:02:39
> > YES! It ihibits the Monoamine oxidace that oxidizes the amino acids serotonin, norepinephrine, and to a smaller extent dopamine. It is NOT an agonist, that is the wrong terminology. An agonist is like Cocaine, for example, which directly mimics dopamine and is therefore a D1 (dopamine suptype 1) agonist cause it stimulates it DIRECTLY. MAOI's don't directly stimulate anything, they just allow your neurotransmitter levels to rise.
>
> Well, you are also mistaken. Cocaine is not a D1 agonist. It is a reuptake inhibitor of Dopamine, Norepinephrine, and Serotonin.
>
>There is some evidence that MAOIs act as indirect agonists of catecholamines...I haven't read anything about MAOIs being serotonin agonists.
This is the end of the thread.
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