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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Peter S. on January 19, 2002, at 19:05:04
I've been combining Mirapex (.25mg/day) with 50 mg Prozac and have had definite success. I'm wondering if anyone out there has used this combo- especially Mirapex- and what there experience has been (side effects etc.) I find the Mirapex causes insomnia or I would go higher.
Thanks for any feedback.
Peter
Posted by Cruz on January 19, 2002, at 23:49:10
In reply to Mirapex plus Prozac?, posted by Peter S. on January 19, 2002, at 19:05:04
Trying .2mg Mirapex,40mg Prozac,50mg Amisulpride for a few days and it has been helpfull. If I try to increase the Mirapex the nausea becomes strong. I've tried many many treatments and I have no idea if this will work in the long run, but its encouraging so far. A full year ago I tried Amisulpride with Adrafinil and it might of slightly helped. I ordered more Adrafinil, I will likely add it to the mix. Keep well.
> I've been combining Mirapex (.25mg/day) with 50 mg Prozac and have had definite success. I'm wondering if anyone out there has used this combo- especially Mirapex- and what there experience has been (side effects etc.) I find the Mirapex causes insomnia or I would go higher.
>
> Thanks for any feedback.
>
> Peter
Posted by TSA West on January 20, 2002, at 2:46:21
In reply to Re: Mirapex plus Prozac?, posted by Cruz on January 19, 2002, at 23:49:10
I wonder if you could increase your Amisulpride dose to 100 mg for maximum effect in your emotional wellness... In clinical trials for dysthymia they used a range of 50-100 mg/day q.d.
Increasing the Mirapex is a viable option for you, and consider using some over-the-counter Emetrol to counter the nausea. If the Mirapex side-effects become too great, consider using the dopaminergic and serotonergic bromocriptine (Parlodel).
With all good intentions in Christ,
TSA West: The New Frontier
Posted by Psydoc on January 21, 2002, at 18:16:05
In reply to Mirapex plus Prozac?, posted by Peter S. on January 19, 2002, at 19:05:04
I have been prescribing Mirapex along with SSRIs for the past several months. Most people seem to be able to tolerate between 0.75 and 1.5 mg per day.
In order to avoid insomnia, I suggest that the Mirapex be taken in two doses, first thing in the AM and about 6-hours later.
Best regards . . .
Ivan Goldberg
psydoc@psycom.net
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%> I've been combining Mirapex (.25mg/day) with 50 mg Prozac and have had definite success. I'm wondering if anyone out there has used this combo- especially Mirapex- and what there experience has been (side effects etc.) I find the Mirapex causes insomnia or I would go higher.
>
> Thanks for any feedback.
>
> Peter
Posted by ChrisK on January 22, 2002, at 2:30:22
In reply to Re: Mirapex plus Prozac?, posted by Psydoc on January 21, 2002, at 18:16:05
> I have been prescribing Mirapex along with SSRIs for the past several months. Most people seem to be able to tolerate between 0.75 and 1.5 mg per day.
>
> In order to avoid insomnia, I suggest that the Mirapex be taken in two doses, first thing in the AM and about 6-hours later.
>
> Best regards . . .
>
> Ivan Goldberg
> psydoc@psycom.net
> %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
These low dosages seem a little odd to me. The studies I've seen about Mirapex indicate that the theraputic dosage is more like 3-6 mg/day taken in three divided doses. I take 2mg early morning, 1 mg late morning and mid afternoon. I've been doing this without problems for over a year now. I did initially have some insomnia but like most other side effects I've ever had, it went away as my body adjusted.I would suggest that anyone taking 1mg/day or less is not going to get the full benefit from Mirapex.
http://www.parkinson.org/mxdepress.htm
Chris
Posted by Elizabeth on January 23, 2002, at 14:16:35
In reply to Re: Mirapex plus Prozac?, posted by Psydoc on January 21, 2002, at 18:16:05
What does Mirapex do? I've never been clear on this (and different people seem to say different things!). The nausea and insomnia sound like dopaminergic side effects.
To people who've tried Mirapex: did it help you, and if so, in what way(s)?
-elizabeth
Posted by ChrisK on January 24, 2002, at 4:49:47
In reply to Re: Mirapex, posted by Elizabeth on January 23, 2002, at 14:16:35
> To people who've tried Mirapex: did it help you, and if so, in what way(s)?
>
> -elizabethFor me Mirapex has alieviated a lot of my anhedonia/apathy. It has given me back some emotions that were long gone. I can actually feel good things again and don't have all of the emotional numbness that a lot of AD's gave me.
I don't pretend to know why it works, just that it does for me. Also I didn't get any of the bad side effects.
Posted by michael on January 28, 2002, at 23:20:53
In reply to Re: Mirapex, posted by Elizabeth on January 23, 2002, at 14:16:35
I believe that it's a dopamine agonist. It's primary use (I think) is for Parkinson's...
...Just looked up the specifics, and found this (pramipexole is the generic name):
Pramipexole is a dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity.
Pramipexole alleviates Parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.
In human volunteers, a dose-dependent decrease in prolactin was observed.
> What does Mirapex do? I've never been clear on this (and different people seem to say different things!). The nausea and insomnia sound like dopaminergic side effects.
>
> To people who've tried Mirapex: did it help you, and if so, in what way(s)?
>
> -elizabeth
Posted by Michael on August 20, 2007, at 11:40:14
In reply to Re: Mirapex, posted by ChrisK on January 24, 2002, at 4:49:47
> For me Mirapex has alieviated a lot of my anhedonia/apathy. It has given me back some emotions that were long gone. I can actually feel good things again and don't have all of the emotional numbness that a lot of AD's gave me.
>
> I don't pretend to know why it works, just that it does for me. Also I didn't get any of the bad side effects.I know that this is an ancient thread, but thought I'd try asking a follow-up anyway... So, just wondering what dose/how much you were taking? Any other comments...? Thanks.
michael
Posted by kingcolon on August 23, 2007, at 13:49:30
In reply to Re: Mirapex » ChrisK, posted by Michael on August 20, 2007, at 11:40:14
>
> > For me Mirapex has alieviated a lot of my anhedonia/apathy. It has given me back some emotions that were long gone. I can actually feel good things again and don't have all of the emotional numbness that a lot of AD's gave me.
> >
> > I don't pretend to know why it works, just that it does for me. Also I didn't get any of the bad side effects.
>
> I know that this is an ancient thread, but thought I'd try asking a follow-up anyway... So, just wondering what dose/how much you were taking? Any other comments...? Thanks.
>
> michaelFor me Mirapex has alieviated a lot of my anhedonia/apathy. It has given me back some emotions that were long gone. I can actually feel good things again and don't have all of the emotional numbness that a lot of AD's gave me.
> >
> > I don't pretend to know why it works, just that it does for me. Also I didn't get any of the bad side effects.
>
> I know that this is an ancient thread, but thought I'd try asking a follow-up anyway... So, just wondering what dose/how much you were taking? Any other comments...? Thanks.
>
> michaelI used Mirapex and also Requip recently, but had to stop because of palpitations which were not even dose related. Low doses were used in the studies on depression--not those in the range used for Parkinson's. It helped with anhedonia, but did cause some fatigue. I also use Cymbalta and Lamictal. I think any dopaminergic is good for people experiencing emotional dulling on SSRI's, and there is probably a subset of people with depression who experience marked benefit from dopaminergics. Here are two great articles on this subject; I bought them as a single article, and for those who are really interested, it's worth it. They are too long to post here.
http://jop.sagepub.com/cgi/content/abstract/21/5/461
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