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Re: Mirapex » Elizabeth

Posted by michael on January 28, 2002, at 23:20:53

In reply to Re: Mirapex, posted by Elizabeth on January 23, 2002, at 14:16:35

I believe that it's a dopamine agonist. It's primary use (I think) is for Parkinson's...

...Just looked up the specifics, and found this (pramipexole is the generic name):

Pramipexole is a dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity.

Pramipexole alleviates Parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.

In human volunteers, a dose-dependent decrease in prolactin was observed.


> What does Mirapex do? I've never been clear on this (and different people seem to say different things!). The nausea and insomnia sound like dopaminergic side effects.
>
> To people who've tried Mirapex: did it help you, and if so, in what way(s)?
>
> -elizabeth


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