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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by geno on January 4, 2002, at 20:58:45
I read a post a while back which made scence. Persons who arent diagnosted with schizofrenia, should first try antidepressants that possess 5ht2 angagonist, such as remeron , or serzone, in stead of anitphsycotic meds which possess 5ht2 antagonistic properties along with dopamine d2 antagonism, such as respirdol or seroquel. I asked for the latter meds, and my pdoc said if im not experiencing dillutioins, hallucinations or thinking "alients are really coming to get me, i should stick with remeron or Gaba drugs, due to my parinoia and anxiety.
geno
Posted by OldSchool on January 5, 2002, at 9:44:32
In reply to Anitphycotics vs 5ht2a receptor drugs, posted by geno on January 4, 2002, at 20:58:45
> I read a post a while back which made scence. Persons who arent diagnosted with schizofrenia, should first try antidepressants that possess 5ht2 angagonist, such as remeron , or serzone, in stead of anitphsycotic meds which possess 5ht2 antagonistic properties along with dopamine d2 antagonism, such as respirdol or seroquel. I asked for the latter meds, and my pdoc said if im not experiencing dillutioins, hallucinations or thinking "alients are really coming to get me, i should stick with remeron or Gaba drugs, due to my parinoia and anxiety.
> geno
This is true Geno. Certain antidepressants possess 5HT2A receptor blocking properties. Specifically Remeron, Serzone and Trazodone all have 5HT2 receptor blocking qualities. But without the dopamine receptor blocking qualities atypical anti-psychotics have.Thus if you have agitated depression, anxiety or agitation in general but are not truly psychotic, why risk movement disorders like EPS with atypical anti-psychotics? Remeron, Serzone and Trazodone are far safer drugs.
Old School
Posted by CalvaryHill on January 6, 2002, at 0:54:39
In reply to Anitphycotics vs 5ht2a receptor drugs, posted by geno on January 4, 2002, at 20:58:45
the Prozac + Zyprexa combination in depression has been proven better than either drug alone. Its because of the synergistic effect on serotonin and Zyprexa's anxiolytic effect.
Posted by OldSchool on January 6, 2002, at 10:02:22
In reply to Re: Anitphycotics vs 5ht2a receptor drugs » geno, posted by CalvaryHill on January 6, 2002, at 0:54:39
> the Prozac + Zyprexa combination in depression has been proven better than either drug alone. Its because of the synergistic effect on serotonin and Zyprexa's anxiolytic effect.
Zyprexa can also induce EPS and other movement disorders, particularly in non psychotic people whose main problem is depression.
The reason Zyprexa and similar atypical anti-psychotics are added to SSRIs in non psychotic TRD is because all atypicals block the 5HT2 receptors. Doing that can make the SSRIs work better sometimes. However you also must remember all atypical anti-psychotics also block dopamine receptors at the same time.
Unless your really psychotic or manic, atypicals is a bad idea.
Old School
Posted by stjames on January 6, 2002, at 19:08:24
In reply to Re: Anitphycotics vs 5ht2a receptor drugs, posted by OldSchool on January 6, 2002, at 10:02:22
> Zyprexa can also induce EPS and other movement disorders, particularly in non psychotic people whose main problem is depression.
>
> The reason Zyprexa and similar atypical anti-psychotics are added to SSRIs in non psychotic TRD is because all atypicals block the 5HT2 receptors. Doing that can make the SSRIs work better sometimes. However you also must remember all atypical anti-psychotics also block dopamine receptors at the same time.
>
> Unless your really psychotic or manic, atypicals is a bad idea.
I highly agree. Atypicals are becoming first line treatment, and the risk is too great. At least till 10-20 years pass and we really know.
Posted by OldSchool on January 6, 2002, at 20:50:24
In reply to Re: Anitphycotics vs 5ht2a receptor drugs, posted by stjames on January 6, 2002, at 19:08:24
>
>
> I highly agree. Atypicals are becoming first line treatment, and the risk is too great. At least till 10-20 years pass and we really know.Yes, I am suffering from this stupid practice in psychopharmacology right now. Have a numb tongue as I am typing this due to EPS from JUST 50 Seroquel taken for slightly over one month! I couldnt believe it myself.
Wait til Eli Lilly gets this Zyprexa/Prozac combo for non psychotic TRD formally FDA approved. LOL Oh shit...there is gonna be a lotta lawsuits a few years after that I bet you.
Its a bad idea, unless youre seeing things, hearing things, thinking aliens landed in your backyard, etc.
Old School
This is the end of the thread.
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