Psycho-Babble Medication Thread 29957

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Re: Laurie

Posted by Leighwit on April 17, 2000, at 14:29:43

In reply to Re: Laurie, posted by Andrewb on April 17, 2000, at 14:08:23

Absolutely sound advice, Andrew. I am fortunate that I have a Pdoc who is willing to think "outside of the box" yet thoroughly researches any suggestions I might bring to her. She consulted with a psychopharmacologist at a teaching hospital here in the Chicago area before agreeing to help me acquire and try Reboxetine. She went to quite a bit of trouble actually. I wish it had been the panacea I'd hoped for. I think I'll stick with my WB/Aricept/Celexa cocktail for awhile. If I experience any worsening of symptoms, though, I think I'll talk to her about Adrafinil.

Without this and another ng I read frequently, I wouldn't have known that drugs such as Reboxetine, or Adrafinil even existed. In fact, I learned about Aricept from reading newsgroups, which is now an important part of my treatment. It puts different medications and topics on my list for further research and potential discussion with my Pdoc. By no means, though, would I try new drugs without back-up research and professional expertise.

Great advice, Andrew.

Laurie


 

Re: AndrewB, neurontin, social anxiey.

Posted by DC on April 17, 2000, at 18:23:42

In reply to RE: DC, posted by AndrewB on April 17, 2000, at 7:47:39

Andrew,

Wow, thanks for all the great information. I'm glad the reboxetine and amisulpride are helping you. I was very interested to read your hyphothesis about subnormal function of D2 receptor. I also think it has something to do with dopamine. The MAOI's all affect dopamine;and lots of time they work better than the ssris. But I also think social anxiety has something to do with gaba receptors. Klonipan is often helpful and so it neurontin. 100mg three times a day might be a good starting dose, but you might need to get up to 300-400mg 3-4/day. The company that makes neurontin is now testing a new drug called pregabalin for anxiety and bipolar disorder. Basically, it's a slightly modified version of neurontin. Right now they conducting a study at Yale Anxiety Disorders Clinic, trying Pregabalin for social phobia. I was going to do it, but decided not because of the restriction on all other meds. I wonder if this drug might work even better for me than neurontin. I'll call the clinic and ask the guy if it seems to be helping people. (But he is so uptight he will probably refuse to say anything).
Good luck, DC

 

ReEuphoria, anhedonia

Posted by Fred Potter on April 18, 2000, at 17:03:20

In reply to Re: Laurie, posted by Leighwit on April 17, 2000, at 13:21:34

I find anhedonia a deeply upsetting part of depression. Things you were passionate about are meaningless, and yet you know there's someone inside you who is still passionate about them but can't connect.

As for euphoria, I reckon we all deserve some of that

Fred

 

JohnL. Re: Q's on new wonderdrug....Adrafinil.

Posted by michael on April 18, 2000, at 19:23:22

In reply to Info on my new wonderdrug....Adrafinil., posted by JohnL on April 14, 2000, at 4:26:06

> I can't seem to access my previous post on Adrafinil and Amisulpride. To make a long story short, Adrafinil has been wonderful at treating my longstanding stubborn anhedonia. Finally something that works! Yes!!
>
> It's hard to find much information on Adrafinil. But the stuff I did find--posted below--I can say from personal experience is completely true. Everything this literature says about Adrafinil is absolutely true and accurate. The drug is everything the literature says it is. What a wonderful medication! Adrafinil...SALUTE!!!
>
>
> ADRAFINIL: What is; (a.k.a. Olmifon) (Description & information below)
> NOTE:not to be confused with "Anafranil (a.k.a. clomipramine)" the Antidepressant.
>
> Adrafinil provides alertness in most without the feeling often felt with stimulants that usually are prescribed for a person with
> narcolepsy. Such as amphetamines etc. Also the possibility of tolerance is low with its continued use. There is however a
> need for certain Liver function tests
> on a regular basis with its continued use. Normally the same types of required testing as with the medication " cylert " which is
> commonly prescribed in the USA. It is also used in certain parts europe as a "antidepressant". It is the combination of
> Adrafinil's releasing stimulantive arousal effect(s), and its antidepressant effects that some doctors in europe recommend
> Adrafinil over its newer form of Modafinil. There have been studies done in the United States "measuring depression in
> individuals with sleep disorders",. In one study it was suggested that the
> "rate of narcolepsy and depression is estimated to be between 30-52%".
>
>
> ADRAFINIL (Olmifon)
>
> Rapidly restores vigilance and alertness in older people and the physically and mentally tired. Has a powerful
> antidepressant action far superior to that of fluoxetine (Prozac) and clomipramine (Anafranil) and is without any serious
> side effects. Adrafinil restores your powers of concentration, memory and intellectual function. When administered to
> older people who have lost interest in life, adrafinil makes them want to take part in life again and they find that they
> have renewed energy and vigor. Adrafinil may be correctly described as an anti-aging drug because it directly combats
> degeneration in the part of the brain that allows you to take pleasure in life. Elderly people very often have disturbed
> sleep patterns and take many naps during the day. Adrafinil restores a youthful sleep/wake cycle of full alertness in the
> daytime and deep restorative sleep at night. After several weeks of treatment with Adrafinil daytime sleepiness
> disappears, interest in intellectual activity is restored and depression lifts. It is very important to note that this improved
> quality of alertness is NOT accompanied with mental excitation and insomnia as occurs with amphetamine or caffeine.
> The correct dosage is 300 to 600 mg per day. The dosage can be adjusted according to response. Remember it takes
> three weeks for all the effects of Adrafinil to become apparent. Do not use Adrafinil if you have any type of kidney or liver
> problem or if you suffer from epilepsy.
>
> Where all other drugs have failed, Adrafinil has quickly become the star my show. I can't say enough good about it. JohnL

Hey John,

Just a couple questions - you mention 300mg - 600mg for dosage, while the package insert thta I got says 600 - 1200. I was just curious of the source for the dosage that you mentioned?

I was also wondering how long it was before you "noticed" anything that you would attribute to the adrafinil? Couple of days, couple of weeks? And if you could label it, would you call it energy? "hedonia"? Ability to concentrate/focus?

And one last dosage question - did you mention that it did affect your sleep for the first few days? And if that's correct, is it fair to say that you haven't had any issues with that subsequently, as long as you don't take any after early afternoon?

Thanks for any info you can provide, and sorry if I'm re-asking question you've already addressed.
michael

 

Provigil, Adrafinal, and Amisulpride

Posted by DC on April 18, 2000, at 17:07:59

In reply to Re: Laurie, posted by Leighwit on April 17, 2000, at 13:21:34

Reading over the posts here, I am getting enthusiastic about these three new drugs.
1. Is provigal the same thing as modafinal, and why is it only being used for narcrolepsy? If it has AD effects?

2. Are these three drugs all in the same class? Are they all stimulant type drugs?

3. Which one do you think would be most likely to help someone with a combination of anhedonia, inattentive add, and social phobia?

I'm sorry I can only ask questions at this point. Any help would be greatly appreciated. Thanks, Dwight

 

Re: Adrafinil....Michael

Posted by JohnL on April 19, 2000, at 2:53:07

In reply to JohnL. Re: Q's on new wonderdrug....Adrafinil., posted by michael on April 18, 2000, at 19:23:22

Michael,

The information I provided--such as the dosing range of 300mg t0 600mg--was copied from a net search. It wasn't my own writing. You are correct that the package label specifies doses of 600mg to 1200mg, but apparently less may work fine.

I noticed immediate effects of Adrafinil in terms of great mood and energy. But that faded in two days. It returned gradually over a period of two weeks in a slow but steady improvement. My mood actually is not as good as it was the first day (three weeks later). But interest, concentration, and motivation are strong. I don't physically feel any more energy than normal, but mentally I just want to do things. Previously, all I could do was keep the couch occupied.

It did indeed affect sleep during the first week. It was terrible. I could fall asleep OK, but then wake just a couple hours later. Midnight insomnia. Not even my Remeron was strong enough to overcome it. That did however disappear completely after a week. I sleep fine now.
JohnL


 

Re: Adrafinil....Michael; thanks johnL

Posted by michael on April 19, 2000, at 3:11:18

In reply to Re: Adrafinil....Michael, posted by JohnL on April 19, 2000, at 2:53:07

> Michael,
>
> The information I provided--such as the dosing range of 300mg t0 600mg--was copied from a net search. It wasn't my own writing. You are correct that the package label specifies doses of 600mg to 1200mg, but apparently less may work fine.
>
> I noticed immediate effects of Adrafinil in terms of great mood and energy. But that faded in two days. It returned gradually over a period of two weeks in a slow but steady improvement. My mood actually is not as good as it was the first day (three weeks later). But interest, concentration, and motivation are strong. I don't physically feel any more energy than normal, but mentally I just want to do things. Previously, all I could do was keep the couch occupied.
>
> It did indeed affect sleep during the first week. It was terrible. I could fall asleep OK, but then wake just a couple hours later. Midnight insomnia. Not even my Remeron was strong enough to overcome it. That did however disappear completely after a week. I sleep fine now.
> JohnL

Hey JohnL,

Thanks for the reply. I had a couple of other things I wanted to ask you come to mind... One was about Ultram (tramadol). I believe it's a pain med (works w/opoid receptors? not sure about that...), but I've seen it mentioned here a couple times in conjunction with alieviating anhedonia. Not that it was prescribed for that, just that people noticed that it seems to help. Just wondering if you've had any experience w/that one - since you mentioned anhedonina as an aspect that's been hard to address?

The other thing was selegiline. If I recall correctly, you had been experimenting w/that as well? Low dosage - 5mg to 15mg? Just wondering if you've left that one behind, or still keeping it in your arsenal, even if not employing it just now. I thought you'd had some positive results...? Think the metabolites might be a bit much in conjunction w/the adrafinil - in terms of stimulation & difficulty sleeping?

Thanks again for all of you time JohnL, responding to me, as well as all the great info you provide in general. michael

Oh, one more thing - as for the adrafinil, have you been going w/300mg am & noon, for dosages & dose timing? Thanks again.

 

Re: Provigil, Adrafinal, and Amisulpride

Posted by JohnL on April 19, 2000, at 3:13:06

In reply to Provigil, Adrafinal, and Amisulpride, posted by DC on April 18, 2000, at 17:07:59

> Reading over the posts here, I am getting enthusiastic about these three new drugs.
> 1. Is provigal the same thing as modafinal, and why is it only being used for narcrolepsy? If it has AD effects?
>
> 2. Are these three drugs all in the same class? Are they all stimulant type drugs?
>
> 3. Which one do you think would be most likely to help someone with a combination of anhedonia, inattentive add, and social phobia?
>
> I'm sorry I can only ask questions at this point. Any help would be greatly appreciated. Thanks, Dwight


Yes, Provagil is Modafinil. Though its designated use is in narcolepsy, it has shown promise in other conditions as well. I think all drugs do actually. For example, Zyprexa for depression or mood stability, not just schizophrenia. Lamictal for depression and mood stability, not just epilepsy. Prozac for OCD, not just depression. On and on. Etc.

Modafinil and Adrafinil are technically psychostimulants, though their profiles are quite different (more subtle, smoother, takes longer) than typical stimulants. Amisulpride is a European antipsycotic technically. But it is somewhat alerting, not often sedating.

For your symptoms, I personally feel any one of these could work better for you than the SSRIs or other standard antidepressants. That's my personal experience anyway. SSRIs and stuff seem pretty effective at relieving depression, but they often don't affect a few core symptoms. Anhedonia seems to be a most stubborn condition, which I think responds better to NE drugs like Adrafinil or Modafinil (or tricyclics), and dopamine drugs like Amisulpride.

I think Adrafinil is worth trying first, because it is easy to get without a prescription, and it's fairly cheap. Modafinil can also be found without a prescription from overseas, but it is very pricey...more so than what you are used to paying for any other psychiatric drugs. Amisulpride requires a prescription, regardless of where you get it, 50 tabs of 200mg are a little over $200. But at 50mg to 100mg a day normal dosage, those 50 tabs will last 100 to 200 days. So the expense isn't too bad, but actually getting it is not as easy as Adrafinil.

I've tried Amisulpride alone, Adrafinil alone, and the two combined. Amisulpride provided amazing social comfort, relaxation, and confidence. But it did little for anhedonia. Adfrafinil is great for both social phobia and ADD and depression, all in one. So again, I tend to lean toward Adrafinil as your first, easiest, and cheapest choice. I am taking both Adrafinil and Amisulpride. Though I'm not 100%, I'm way better than on any of the dozens of antidepressants and things I've tried over the years.
JohnL

 

JohnL-amisulpride

Posted by michael on April 19, 2000, at 3:47:53

In reply to Re: Provigil, Adrafinal, and Amisulpride, posted by JohnL on April 19, 2000, at 3:13:06


Hey JohnL-

I tried it, and I was out like the proverbial light bulb - slept 12+ hours/day.

However, it just recently occured to me that I still had prozac in my system (had been taking 20mg/day) while I was trying the amisulpride - I had almost no wash-out period between the meds. Think it might affect me differently now, w/o the prozac in my system? I'm planning to give adrafinil a shot, begining tomorrow... anyway, thanks again... michael


> > Reading over the posts here, I am getting enthusiastic about these three new drugs.
> > 1. Is provigal the same thing as modafinal, and why is it only being used for narcrolepsy? If it has AD effects?
> >
> > 2. Are these three drugs all in the same class? Are they all stimulant type drugs?
> >
> > 3. Which one do you think would be most likely to help someone with a combination of anhedonia, inattentive add, and social phobia?
> >
> > I'm sorry I can only ask questions at this point. Any help would be greatly appreciated. Thanks, Dwight
>
>
> Yes, Provagil is Modafinil. Though its designated use is in narcolepsy, it has shown promise in other conditions as well. I think all drugs do actually. For example, Zyprexa for depression or mood stability, not just schizophrenia. Lamictal for depression and mood stability, not just epilepsy. Prozac for OCD, not just depression. On and on. Etc.
>
> Modafinil and Adrafinil are technically psychostimulants, though their profiles are quite different (more subtle, smoother, takes longer) than typical stimulants. Amisulpride is a European antipsycotic technically. But it is somewhat alerting, not often sedating.
>
> For your symptoms, I personally feel any one of these could work better for you than the SSRIs or other standard antidepressants. That's my personal experience anyway. SSRIs and stuff seem pretty effective at relieving depression, but they often don't affect a few core symptoms. Anhedonia seems to be a most stubborn condition, which I think responds better to NE drugs like Adrafinil or Modafinil (or tricyclics), and dopamine drugs like Amisulpride.
>
> I think Adrafinil is worth trying first, because it is easy to get without a prescription, and it's fairly cheap. Modafinil can also be found without a prescription from overseas, but it is very pricey...more so than what you are used to paying for any other psychiatric drugs. Amisulpride requires a prescription, regardless of where you get it, 50 tabs of 200mg are a little over $200. But at 50mg to 100mg a day normal dosage, those 50 tabs will last 100 to 200 days. So the expense isn't too bad, but actually getting it is not as easy as Adrafinil.
>
> I've tried Amisulpride alone, Adrafinil alone, and the two combined. Amisulpride provided amazing social comfort, relaxation, and confidence. But it did little for anhedonia. Adfrafinil is great for both social phobia and ADD and depression, all in one. So again, I tend to lean toward Adrafinil as your first, easiest, and cheapest choice. I am taking both Adrafinil and Amisulpride. Though I'm not 100%, I'm way better than on any of the dozens of antidepressants and things I've tried over the years.
> JohnL

 

Re: Adrafinal Query (hope it's not redundant)

Posted by CarolAnn on April 19, 2000, at 9:55:21

In reply to Re: Provigil, Adrafinal, and Amisulpride, posted by JohnL on April 19, 2000, at 3:13:06

I keep reading in this thread that Adrafinal is easy to get without a prescription, but I haven't seen anything(or maybe I missed it) about whether you can get it *with* a prescription from your Pdoc. The way my insurance works I would only have to pay $8.00 per month's supply. Also, is that cheaper then just ordering the stuff on my own? Thanks, in advance, for the info! CarolAnn

 

Re: Adrafinal Query (hope it's not redundant)

Posted by michael on April 19, 2000, at 10:31:21

In reply to Re: Adrafinal Query (hope it's not redundant), posted by CarolAnn on April 19, 2000, at 9:55:21

> I keep reading in this thread that Adrafinal is easy to get without a prescription, but I haven't seen anything(or maybe I missed it) about whether you can get it *with* a prescription from your Pdoc. The way my insurance works I would only have to pay $8.00 per month's supply. Also, is that cheaper then just ordering the stuff on my own? Thanks, in advance, for the info! CarolAnn

CarolAnn-

Adrafinil isn't approved by the FDA, and therefore isn't available in the US. You can order it from abroad.

Btw - the dosage seems to be 300mg to 1200mg per day (or 1 to 4 pills per day), so if you can get your insurance to subsidize you, $8 per month is definitely cheaper.

If you can get a script, you may be able to get it cheaper via a french pharmacy - I once saw someone else mention that it was roughly $12 for a box of 40x300mg, or $40 for 160x300mg in france.

But don't know how your insurance co. would deal with/feel about covering a med not approved by the FDA...?

Good luck! & let us know how that works if you persue this w/your ins. co. - I'd be curious about their reaction. michael

 

Re: Provigil, Adrafinal, and Amisulpride

Posted by AndrewB on April 19, 2000, at 13:22:44

In reply to Provigil, Adrafinal, and Amisulpride, posted by DC on April 18, 2000, at 17:07:59

Dwight,

You don't have to try just one. I take reboxetine and amisulpride and they both help. Amisulpride makes me less socially anxious and it also works as a prohedonic. Reboxetine works to get me out and do things such as sociallize. Adrifinil seems to do the same thing. One good reason to do a trial with amisulpride is that it is easy. The trial will only take 5 days to a week to decide whether amisulpride will work for you, it acts that fast. And since you are a man, you shouldn't expect to have to experience much in the way of side effects during your trial.

Dwight, what is inattentive ADD?

AndrewB

 

Re: Provigil, Adraf...to:AndrewB

Posted by Ant-Rock on April 19, 2000, at 17:49:01

In reply to Re: Provigil, Adrafinal, and Amisulpride, posted by AndrewB on April 19, 2000, at 13:22:44

Hi again Andrew,
Hope all is well. How is the rebox-amisulp combo working? Sounds like your doing well, hope that is the case. JohnL's posts sure were exciting to read. I love to hear about ones life being turned around do to their will to live and perseverence.
Anyway, thanks in advance,
Anthony

 

Andrew…inattentive ADD

Posted by Janice on April 19, 2000, at 22:38:17

In reply to Re: Provigil, Adrafinal, and Amisulpride, posted by AndrewB on April 19, 2000, at 13:22:44

Hi Andrew,

From what I understand, there are a group of people with ADD who have never been hyper (mostly women) but still have ADD. Instead of being hyper, they have always been hypo. It looks very much like depression and often is accompanied with a low grade chronic depression.

One good way to tell it apart from depression is that the symptoms go back into childhood--maybe not the depression symptoms.

I don't know why there is so little decent information about it. I would never have known it existed by reading any ADD sites. I think it is a new diagnosis within the past 5 years. These are probably the people who think they are depressed, and have been depressed for SO long, they finally in desperation try a stimulant…which WORKS. The medical profession, up until recently, thought some people's 'depression' could only be treated with stimulants.

Take care Andrew, Janice

 

Adrafanil......ordering into Canada....?

Posted by Paul S. on April 20, 2000, at 1:56:24

In reply to Info on my new wonderdrug....Adrafinil., posted by JohnL on April 14, 2000, at 4:26:06


I am interested in trying Adrafanil but am going to run it by my doctor first. It is not available in Canada and was wondering if anyone knew if there are any concerns/problems I should be aware of in ordering from out-of-country into Canada.
Thanks!
PaulS

 

Re: Provigil, Adraf...to:AndrewB

Posted by AndrewB on April 20, 2000, at 7:41:08

In reply to Re: Provigil, Adraf...to:AndrewB, posted by Ant-Rock on April 19, 2000, at 17:49:01

Hey Anthony!

I'm trying to keep track of people's different responses to amisulpride. Could you please sum up for me what it has or hasn't done for you. Have you found anything to improve your energy.

I'm doing fine myself. I added amineptine onto the other meds with good results so far. It is good for energy, drive, and confidence.

AndrewB

 

Thanks John L., etal...

Posted by ChrisK on April 20, 2000, at 8:07:39

In reply to Re: Provigil, Adrafinal, and Amisulpride, posted by AndrewB on April 19, 2000, at 13:22:44

I went to my pdoc yesterday loaded with info on Adrafinil and others because I still suffer from the Anhedonia that seems to be the last part of Depression that escapes me. My pdoc gave me a prescription for Monafidil to replace my Adderall. I'm not expecting the magic potion but do hope that the new meds will get me over the "happy hump" that I seem to be stuck on. I still hope that there is something that will give me a certain happiness.

At least for now, I have some hope.

Thanks for all of the info during the last month,

Chris K

 

Re: Provigil, Adraf...to:AndrewB

Posted by Ant-Rock on April 20, 2000, at 8:17:46

In reply to Re: Provigil, Adraf...to:AndrewB, posted by AndrewB on April 20, 2000, at 7:41:08

Andrew,
I really don't notice any difference on the amisulpride. I still take 50mg/day, but i did try 100/day for a week w/no changes. I feel the Ritalin is helping the most with mood, I'm upping to 15mgRitalin today and if I still only get partial response, can go to 20mg/day.
Anyway I believe large component of my fatigue is due to my low cortisol levels(mild adrenal insufficiency). I've found lots of good info regarding low-dose cortisone therapy for my condition. Treatment is not well understood by most doctors, but is very beneficial and SAFE at physiological doses.
I believe this is my best bet. Low cortisol liked to fatigue, brain fog, depression, multiple allergies. I qualify for all these.(Lucky me!)
Anyway, thank you again for your quick reply Andrew, I'll keep you posted.
Take care,
Anthony

 

Re: Provigil, Adraf...to:AndrewB

Posted by AndrewB on April 20, 2000, at 9:19:51

In reply to Re: Provigil, Adraf...to:AndrewB, posted by Ant-Rock on April 20, 2000, at 8:17:46

Anthony,

I'll keep an eye out for hydrocortisone tablets. Thanks for the amisulpride update. Amineptine is $3.85 for 10 pills.

 

Re: AndrewB - amineptine/amisulpiride

Posted by KarenB on April 20, 2000, at 10:53:43

In reply to Re: Provigil, Adraf...to:AndrewB, posted by AndrewB on April 20, 2000, at 7:41:08

Andrew!

You are taking amineptine with amisulpiride, correct? So, how is that combo working for you? As you know, I think amineptine plus sulpiride is the bomb. Please let me know - I am very interested in that particular combination. I hope it works as well for you as the other did for me. If so, you should be out mountain climbing in no time.

Your friend in the pursuit of wellness,

Karen

 

Re: AndrewB - amineptine/amisulpiride

Posted by AndrewB on April 20, 2000, at 11:17:06

In reply to Re: AndrewB - amineptine/amisulpiride, posted by KarenB on April 20, 2000, at 10:53:43


> Karen,

Karen, I was inspired by you to try amineptine again, but this time with
amisulpride. Whereas side effects only allowed me to take a suboptimal dose of
amineptine before when I was taking it alone, now in combo with amisulpride I
am able to take a full dose. I am merely using an old supply I had. But I have
been assured by the Indian company that supplies are assured for now at least.
From all that I have read, sulpiride and amisulpride are very, very similar. And
yes, my energy is way up there right now, along with improved drive and social
confidence. If this effect lasts for 3 weeks I will order more amineptine.

 

Mirapex vs. amisulpride

Posted by DC on April 20, 2000, at 18:31:06

In reply to Re: AndrewB - amineptine/amisulpiride, posted by AndrewB on April 20, 2000, at 11:17:06

Could someone tell me the difference if any between mirapex and amisulpride? Any reason to prefer the latter over the former? Thanks, Dwight

 

Re: JohnL - answers

Posted by Scott L. Schofield on April 21, 2000, at 10:40:56

In reply to Re: JohnL - answers, posted by KarenB on April 21, 2000, at 9:50:53

> Whoever is responsible for it's discontinuation...well let's just say I'd like five minutes with them. It was used in Europe for decades, with great results for thousands. If "potential for abuse" is a reason to stop a great medication, why is valium still around - and a host of others? Go figure. Can you tell I'm a little fired up about this?


You took the words right out of my keyboard.

I bet the International Olympic Committee was responsible for this.
:-)
:-(
>:-<

- Scott

 

Re: Mirapex vs. amisulpride

Posted by AndrewB on April 21, 2000, at 11:12:50

In reply to Mirapex vs. amisulpride, posted by DC on April 20, 2000, at 18:31:06

> Could someone tell me the difference if any between mirapex and amisulpride? Any reason to prefer the latter over the former? Thanks, Dwight

Dwight,

Without getting into details, both meds act pretty much on the same dopamine receptors in the brain but they go about it different ways. Choosing between the two drugs can be based on several criteria. Let's compare:

Amisulpride has been extensively studied for depression and is well proven. There are only 3 or 4 small studies that have been done on Mirapex for treating depression but the results of the studies were promising.

Amisulpride is commonly used for depression in parts of Europe. Mirapex, at the present time, is only rarely used for depression.

Amisulpride must be ordered from overseas (with or without a prescription) while Mirapex is available in the US. I have produced an information piece on amisulpride that can be shown to one's psych. in order to obtain a prescription. Email me at andrewb@seanet.com and I will send it.

Amisulpride costs about 60 cents per dose while Mirapex costs usually over a $1.50/dose. But Mirapex's cost, being available in the US, may be covered in part by insurence.

Amisulpride very rarely has side effects in men but 5% to 10% of women using amisulpride will quit using it due to endricrinological side effects like missed menses and breast swelling. Mirapex will cause nausea and headaches at first, sometimes severe, but these side effects will pass.

AndrewB

 

Re: JohnL - answers

Posted by michael on April 21, 2000, at 11:30:17

In reply to Re: JohnL - answers, posted by Scott L. Schofield on April 21, 2000, at 10:40:56

> > Whoever is responsible for it's discontinuation...well let's just say I'd like five minutes with them. It was used in Europe for decades, with great results for thousands. If "potential for abuse" is a reason to stop a great medication, why is valium still around - and a host of others? Go figure. Can you tell I'm a little fired up about this?
>
>
> You took the words right out of my keyboard.
>
> I bet the International Olympic Committee was responsible for this.
> :-)
> :-(
> >:-
> - Scott

Hey everyone -

Not to be too negative, but I have yet to find or hear that Amineptine is going to continue to be mfg'd in the future. I would love to hear otherwise - but as of yet, I'm skeptical.

I know that it can still be purchased from abroad... But the one source that I know of has never replied to my enquiries regarding the future availability/mfg of amineptine. And previously they had replied to my correspondences w/in 24 hours...

Don't get me wrong, I hope it still will be available - I'd like to try it myself. But as JohnL pointed out, I don't want to get started with it just to have the rug pulled out from under me, especially if it were to help... I'm just afraid that this is just another case of running down the current stock - and then we're all out of luck.

So I guess what I want to know, is does anybody KNOW if it's still MANUFACTURED?


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