Posted by Crotale on July 27, 2008, at 22:16:29
In reply to Re: anyone have experience with pindolol augmentat » Crotale, posted by JohnnyBLinux on July 16, 2008, at 0:56:14
> I take pindolol for high blood pressure. I would say that the combination of Lexapro + pindolol has not resulted in an enhancement of Lexapro. Again, it's hard to say because I didn't start with Lexapro.
Well, it's not necessarily supposed to enhance them so much as make them start working faster ("acceleration" would have been more accurate than "augmentation," really). Which would be pretty cool, if it actually works. In my experience one of the most difficult things about ADs is that it takes so long to find out if they work. Even if they do, not having any response for several weeks is, well, painful. And having to wait six weeks just to find out that an AD *doesn't* work, well, that's pretty frustrating.
In response to the quote from drugs.com...that's just a possible interaction between MAOIs and beta blockers in general. I've found propranolol fine with MAOIs (although beta blockers may not be the best choice for lowering blood pressure in the case of MAOI-sympathomimetic interactions because beta blockers are actually vasoconstrictors).
I was curious about the possibility of serotonin syndrome as a result of pindolol's blockade of serotonergic autoreceptors. Your drugs.com monograph doesn't mention that issue.
(I doubt any drug monograph will discuss this special quirk of pindolol. I was hoping we might have some brave/crazy person here like Scott -- no offense Scott, you impress me, it's just that I'm still in a state of disbelief & shock over your daring to combine a nonselective irreversible MAOI with imipramine without actual suicidal intentions...err, at least I assume you didn't have suicidal intentions -- who had tried it.)
poster:Crotale
thread:838118
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/842496.html