Posted by tealady on October 5, 2006, at 21:33:38
In reply to Re: whats up with GABA ?, posted by sregan on September 25, 2006, at 16:16:40
> It had some effect for me allowing me to sleep a little deeper. I take about .25 klonopin at night and was trying to find a way to enhance that. Unless there are GABA receptors outside the BBB (is the limbic system outside the BBB?) or I've heard in some cases of CFS the patient suffers from an increased permeability of the BBB which could explain why some can benefit from GABA. L-Glutamine seems to have about the same effect for me as GABA.
>
> Theanine definitely works for me better than anything else GABA related. On the flip side down regulating NMDA is supposed to do the same thing which would call for Magnesium and Taurine (that I know of).
>
> Shawn
>
> > It does, I even got a formula with no b6 just to be sure.
> >
> > Someone said it was working by increasing gaba in the periphery? Didn't really buy that. I didn't know I was anxious in the periphery (?)
> >HI Shawn,
Not sure if yu read my past above.
It mentions (in links) probably the reason for the increased permeability of the BBB towards GABA in CFS.
Some CFS respond well TO B1. Bronwyn on my blog under CFS
http://tealady-health.blog.co.uk/?tag=b1 headings
.. says its a complete cure for her..so far, at least complete remission.
I've found B1 also helped my stay asleep.. and nothing else ever has much, except oestrogen (which would incr B1 anyway as it binds it..allowing for a slower release in body so it doesnt deplete as much?, excepting if you have high estrogen(and proabably also applies to testosterone in males) as in some young people late teens early twenties maybe when high levels may bind just too much if lowish on B1.. I'm thinking this may have happened to Browyn as she didn't need any at age 25 after 3 years of injections of B1 , which would restored all pathways /levels, receptors etc)Besides helping me stay asleep (with low cortisol in evenings/nights I had no trouble falling asleep eithere and would wake around 3AM with the cortsiol rise as well).,.. but my midnight salive cortisol was low (undetectable), and morning was normal.
I've also like magnesium and taurine .. taken together as Mag taurate as well..
Mg also works in same pathways as B1.. as does some B2 and biotin and some B6.. , but Mg is used in many places.I also felt low in melatonin and was able to build back up with a few weeks (not long,) l-tryptophan at the beginniing of this year.. but then it felt like too much after a short time.
I also found that my melatonin felt at elast mostly restored on taking B1 injections. I can tolerate a tiny bit of light at night now, and don't seem to feel short.
I have no idea how this works, except that B1 does incr serontonin as well as dopamine;
same lik as above under B1 and CFS/M.E.also under
B1 and myofascial and tooth pulp pain for serotonin links.just a thought
Another friend of mine is reporting recovery slowly by incr B1 via foods ..like liver(or liver extract) and brewers yeast and wheatgerm etc(as well as a low dose multiB, about 5 times RDA).. and then adding in B3 at 100mg-250mg per day and then folic acid
He also had depression with anxiety and problems staying asleep for more than a couple of hrs at a time.
Last thing, my depression was also the high anxiety type.. the anxiety and depression lifted with B1.. not completely(maybe 60-70% better so far after 3 months of injections of B1 , as well as a multi B, biotin 5mg daily and additional B2 , B6, Mg, Ca); as some is situational I guess, but I can now view things withut panicing and think on things more evenly and without the high anxiety I had before.. I suspect I'll always be a worry guts and like to nut things out in my mind a bit.
Hope this is of some help to you or anyone
Jan
poster:tealady
thread:688741
URL: http://www.dr-bob.org/babble/alter/20060817/msgs/692241.html