Posted by Elroy on April 24, 2005, at 20:19:29
In reply to Re: Arghhh » Elroy, posted by gromit on April 24, 2005, at 19:15:26
smi2le seems to have gotten a new business manager to run things (a guy named Jeff). He has actually responded to a couple of my e-mails and informed me about the Idebenone and Sulbutiamine being on long-term backorder.
I have found that I have a very sensitive response to anything that increases NE levels... which is surprising seing as how my NE levels are so low.
One DLPA caplet of 500 mg was a definite increaser of anxiety and physical symptoms. Ditto with one 5mm mg caplet of the just the D version, just not as bad. Decided to go with the tyrosine.
I started out with one 500 mg tablet of Tyrosine... and had increased anxiety and physical symptoms. I cut it in half (250 mg now) and still had reactions (though somewhat lesser). I cut it in half again... and found that I could tolerate that.
Ditto with the Selegiline. 5mg tablet would cause increase in anxiety and physical symptoms, but cutting it in half (2.5 mg) was tolerated. Will have to slowly and gradually work up to therapeutic doses.
Once I get used to the 500 mg dose of tyrosine I then want to try the DLPA (again starting at lower doses).
When one's NE level is a 26 and the normal range is something like 80 to 520.... well, pretty obvious that something needs to be done.
What was interesting is that aerobic type exercises don't boost NE levels significantly. I can use a rebounder, stationary bike, elliptical machine and power walks and not have any reaction. But if I do any weight lifting or intensive calisthenics, within 2 - 4 hours later I have a reaction (increased anxiety, increased physical symptoms, etc.).
And, yes, same-same after sex (which is known to boost NE along with other hormones and neurotransmitters)... of course I just make sure and take a Xanax afterwards!
Actually I have found a lot of relief with using the Taurine. I am using it in combination with GABA (both bought in bulk powder). Along the lines of 1 to 1.5 gram Taurine with 1/2 to 3/4 gram of GABA. Seems to have allowed the cutting back of both the Xanax and Neurontin and the use of Ambien as a sleep aid rather than the Restoril.
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X> Hi Elroy,
>
> Thanks for the links, I've read most of them I think but had a drive die a while back and lost quite a bit of stuff I'd saved. I was feeling pretty discouraged when I posted, it's not as bad as I made it sound.
>
> He was willing to increase selegiline past the point where it's MAO-B selective, he doesn't think it's as effective as parnate or nardil. He said I could try those too but I'm at least going to hold out for the Ensam patch before I go down that road.
>
> I'm not sure why he doesn't want to combine something else with a low dose, especially since during our first visit he said it was more useful as an augmentor. I really don't think it's a safety issue despite what he said, I think he just wanted to steer me in a different direction. I'll go along for now, he's a huge improvement over my last pdoc. Maybe Cymbalta at 60 mg will be the ticket. I've already tried it but at 30 mg and only for a month. He said there is a huge jump in response at 60.
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> I was a little out of sorts that day, although I confirmed the appointment the day before I still forgot about it until 15 min beforehand. I can't believe I actually made it, and then he caught me off guard. I wasn't prepared to argue to stay on it, I thought that was the plan.
>
> Elroy have you checked with smi2le.biz lately? They just updated their site, here is a quote.
>
> "Normally SMIČLE ships all products next business day except for Idebenone, Centrophenoxine, Creatine Monohydrate, L-theanine, R-lipoic acid (powder - we have capsules in stock) and Sulbutiamine, which are on hiatus until all back orders are fulfilled, and they have been removed from the order form."
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> I don't remember if you mentioned what you ordered, but the creatine I didn't get is on that list.
>
> Not sure if I just missed it before but apparently smi2le means Space Migration... Intelligence Squared... Life Extension. I don't know if that makes any more sense but I was wondering.
>
> Anyway thanks for the response and good luck with low dose deprenyl, I'm sure it will be a good experience. I can't think of one negative thing about it and I can't say the same of the other drugs I've tried.
>
>
> Thanks,
> Rick
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poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/488984.html