Posted by Elroy on March 9, 2005, at 21:37:43
In reply to Selegiline, therapeutic dose for depression?, posted by mogger on March 9, 2005, at 19:26:36
I am by no means an MD, but I would personally be much more inclined towards going with LOW DOSE Selegiline (that means 15mg or less, usally more specifically 5mg or 10mg) combined with low-to-moderate dose of amino acid DLPA. Not only seems to be a much "safer" way to go, but my research indicates that much more positive results are gained with this approach.
Either have her doctor research that aspect, or maybe provide him yourself with some printed out articles from some of these links:
http://www.smart-drugs.com/ias-Info/ias-deprenyl.htm
QUOTE: Depression Several studies have suggested that like non-selective monoamine oxidase inhibitors such as phenelzine, selegiline may be of some benefit in depression. Mendlewicz and Youdim reported a marked improvement in 14 patients with unipolar or bipolar depression who received selegiline hydrochloride 5 mg three times daily for 40 days compared with 13 patients given placebo. (1) Similarly, Birkmayer et al. reported benefit in an uncontrolled study in 102 outpatients and 53 inpatients with unipolar depression who received selegiline hydrochloride 5 to 10 mg daily in association with phenylalanine 250 mg daily- about 70% of these patients, in whom conventional antidepressants were not effective, were reported as having complete remission. END QUOTEI don't have the sources for these handy, but:
QUOTE: Several studies have suggested that like non-selective monoamine oxidase inhibitors such as phenelzine, selegiline may be of some benefit in depression. Mendlewicz and Youdim reported a marked improvement in 14 patients with unipolar or bipolar depression who received selegiline hydrochloride 5 mg three times daily for 40 days compared with 13 patients given placebo. (1) Similarly, Birkmayer et al. reported benefit in an uncontrolled study in 102 outpatients and 53 inpatients with unipolar depression who received selegiline hydrochloride 5 to 10 mg daily in association with phenylalanine 250 mg daily- about 70% of these patients, in whom conventional antidepressants were not effective, were reported as having complete remission. (2) END QUOTE
QUOTE: The antidepressive efficacy of L-deprenyl (5-10 mg daily) plus L-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of L-phenylethylamine in the brain. END QUOTE
http://www.selegiline.com/pea.html
http://www.dr-bob.org/babble/20041211/msgs/430276.html
Note: L-deprenyl and Segeline are same thing. DLPA is a form of phenylethylamine that combines both the D-version and the L-version...
Just my thoughts on this. Have doctor check out this possible option as both a better and safer alternative???
> Hi there, my sister is trying Selegiline and her doctor has her at 20 mg per day for her depression. Is this the normal dose? Many thanks for your thoughts,
> mogger
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050225/msgs/468998.html