Posted by linkadge on November 11, 2004, at 14:45:18
In reply to Re: dopamine autoreceptor problem » linkadge, posted by KaraS on November 11, 2004, at 13:46:47
Amisulpride is a dopamine autoreceptor antagonist. However, it also blocks some of the postsynaptic receptors. This kind of cancells out the effect. You get more dopamine but some of its targets are blocked. This is why it is more of a antipsychotic than antidepressant.
I would assume that increasing dopamine could desensitize the autoreceptor in the same way that SSRI's eventually desensitize the serotonin autoreceptor.
I would assume that selegeline would have a similar effect to parnate in this regard.
Right now I am just taking lithium, and epival, and coffee. Coffee really helps calm me down.
With regards to improving anhedonia, I exercise a LOT, and combine this with chocolate.Exercise itself can drastically raise levels of PEA in the brain. I am hoping that combining this with chocolate can deal a double whammy.
I live in canada, and not too many doctors have started experimenting with selegeline for depression.
Linkadge
poster:linkadge
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/414624.html