Posted by karaS on October 17, 2004, at 17:16:40
In reply to Re: Supplements for brain fog? » karaS, posted by raybakes on October 17, 2004, at 14:06:20
> Hi Kara, do you know what dopamine receptor is hypersensitive with you? Seen that there are D1, D2, D3, D4, and D5 receptors - the hypersensitivity of D2 seems to be linked with schizophrenia and anxiety - things like coffee tea, chocolate, vitamin A, biopterin, l-dopa, forskolin and biopterin are linked to receptor sensitivity in different dopamine receptors.
>
> Here's one abstract as an example..
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8263772
>
> Ray
Unfortunately I don't know which one or ones are involved yet. I have to do more research (if it's even possible for me to figure that out). I certainly hope it's not the Parkinson's (D1?)related receptors. I also recently read (if I'm understanding this correctly) that the problem might instead be with the 1-b adrenergic receptors. They seem to serve as a "trans-synaptic mechanism" which can render the dopamine itself as nonfunctional and would therefore have the same effect as hypersensitive autoreceptors.At any rate, the last sentence of the abstract (copied below) that you provided was very encouraging. It suggests that it is indeed possible to treat this kind of hypersensitivity (at least with respect to the D1 receptor). I'm hopeful that has implications for the other D receptors as well.
"Our data suggests that chronic L-dopa/carbidopa treatment reverses the increased dopaminergic activity and D1 receptor functional supersensitivity seen after 6-hydroxydopamine lesions, and indicates a D1 receptor-mediated action of L-dopa"
Thanks Ray
poster:karaS
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404195.html