Posted by raybakes on September 24, 2004, at 7:02:06
In reply to Re: Supplements for brain fog?- Larry » raybakes, posted by tealady on September 24, 2004, at 4:47:00
Hi Jan, looked up a few things for you to read!
>I've got hashimotos too(anti TPO, Anti TG) ..and probably a bit more on the autoimmune side going on.(not tested)
found this abstract explaining that interleukin 1 lowers TG...
http://endo.endojournals.org/cgi/content/full/138/5/2043
I think I need more ACTH. I'm sorry but I get lost trying to follow most of these articles. I see that interleukin 1? stimulates ACTH possibly?
Now what is interleukin 1.?Interleukin 1 is a pro-inflammatory cytokine (messenger of the immune system). In autoimmune disease it seems likely that excessive interleukin 1 can overdrive the adrenals to exhaustion. I have a genetic error in my interleukin 1ra gene that would naturally inhibit IL 1. Trying to drive the adrenals even harder with more ACTH when they're exhausted might not be a good idea!
>I find tyrosine seems to give me lots of dopamine I think. I know I can deaden tooth pain from a hole in a tooth completely with just 500mg tyrosine a day (repeatedly) and other aches in body.
I've also found out (about a year ago) that anesthetic , like prilocaine for dental work has NIL effect if no adrenaline is added..apparently I don't vasoconstrict?Tyrosine is also the precursor to T4 and T3, T4 has four iodines added, and T3 has four added and one taken away. So I wonder if the tyrosine gives your thyroid a boost...heres a bit about thyroid and pain threshold..
"A subset of patients with thyroid hormone deficiency caused by Hashimoto's has a lowered pain threshold. The susceptible patient perceives as painful stimuli that aren't painful to other people. The pain results from too little thyroid hormone regulation of certain nerve cells. Some of the cells, mainly in her spinal cord, when under-regulated by thyroid hormone, release excess amounts of "substance P." The excess substance P then amplifies the transmission of "pain" impulses in the central nervous system."
>Any ideas if tyosine would produce IL1?
don't think so, although IL1 does seem to have a tyrosine related receptor.
>or if thyroid meds like synthetic T4 would make things worse...I am trialling adding in T4 to my Armour?
Found this abstract that says that interleukin 1 can inhibit the conversion of T4 to the more active T3, so if interleukin 1 is part of your problem adding T4 may not be of much benefit - selenium is important for the conversion, and also stops the production of reverse T3, which antagonizes T3...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7627812
>Sorry, I'm lost here,I get lost frequently, so just try to absorb stuff by osmosis! When I've seen things written a few times, it slowly starts to make sense!
Ray
poster:raybakes
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/394437.html