Posted by Larry Hoover on August 21, 2004, at 9:06:06
In reply to magnesium and joints, posted by gardenergirl on August 21, 2004, at 8:06:04
> Hi all,
> I am currently taking 500mg of magnesium oxide per day.Magnesium oxide is the least effective source of magnesium of them all. It is actually so poor, it stands quite apart from the rest. The chemical formula can be represented as Mg=O. That's a double bond to a single oxygen atom. Oxygen atoms do not dissolve, and thus, the magnesium cannot either. The only way to get them apart is a multi-step chemical reaction that consumes stomach acid (mag oxide is an antacid), and the bioavailability is only about 18%.
> I remember a neuropsychologist I worked with, who also is a PhD in physiology or pharm.D (I forget...very smart man) said that too much magnesium could lead to loosening of the joints. Anyone know about this?
Loosening of the joints? I think you maybe remember it backwards?
Joint laxity is caused by magnesium deficiency. Joint tension is maintained by ligaments, and ligaments have their elasticity due to chelation of magnesium ions on the surface of the proteins called elastin.
Too much pretty much can't happen, unless your kidneys do not work properly.
> And how much is too much?
There is too much in the sense of digestive disturbance. Too much dissolved magnesium ions in the gut pulls water out of the intestinal wall, diluting the contents, and causing diarrhea. If you're already magnesium deficient, this is actually more likely to occur. Tolerance will build, if you cut the dose a bit, and wait a while, before increasing it back up again. You also need vitamin D (85% or more of North Americans are vitamin D deficient....rickets is on the increase in North America, despite fortification of dairy products).
> Wish I could have asked him then, but I think it was an in-passing conversation.
>
> Thanks,
> ggWhy are you taking magnesium, if you fear it might be risky?
Lar
poster:Larry Hoover
thread:380304
URL: http://www.dr-bob.org/babble/alter/20040815/msgs/380322.html