Posted by undopaminergic on April 11, 2023, at 10:34:33
In reply to Re: To SLS » Roslynn, posted by SLS on April 10, 2023, at 21:09:03
>
> Theoretically, taking two drugs that increase serotonin neurotransmission - even if they have different mechanisms - have the potential to cause Serotonin Syndrome.
>Not "even", but "especially", because of the potential for synergistic effects, as in the case of MAOI+SSRI. SSRI+SSRI would be merely additive, and moreover, there is a peak of 100% reuptake inhibition which is insufficient to cause life-threatening serotonin toxicity. Venlafaxine (Effexor), however, seems to be more potent in elevating serotonin according to Gillman; he speculates that it may have serotonin-releasing properties.
> > Or can you taper Effexor while starting up Serzone?
>
> I doubt doing that would reduce any risks.Tapering would allow you time to notice early signs of serotonin toxicity, so that you can stop tapering, and if necessary, reduce the dose.
-undopaminergic
poster:undopaminergic
thread:1122008
URL: http://www.dr-bob.org/babble/20230117/msgs/1122012.html