Posted by undopaminergic on December 28, 2022, at 16:11:51
In reply to Re: Finally trying vortioxetine -- initial impressions » undopaminergic, posted by SLS on December 28, 2022, at 14:27:42
> Hi, UD.
>Hi SLS.
> I had been following cariprazine for a few years while it was under development. I really wanted the the increased ratio of dopamine D3/D2 receptor binding. It hurt more than it helped for my bipolar depression.
>
> For me, the following antipsychotics produced an improvement in depression:
>
> risperidone
> aripiprazole
> asenapine
> olanzapine
>Risperidone was the worst I've tried, but that was in a different era (beginning of 2000s decade). I might react differently to it now.
Aripiprazole was without benefit, but stimulated salivation and induced an (eye) accommodation disorder. I had better luck with dopamine pure agonists (pramipexole), but the initial (and unique) anti-anhedonic effect was quickly lost, and I did not try high doses.
Asenapine is one I'd like to try.
Olanzapine has sometimes had a short lived beneficial (less apathy) effect at first. Otherwise it makes me tired and has a tendency to stimulate appetite.
I've also tried other antipsychotics. Sulpiride is the most impressive of them. At first (at low doses) it was a stronger stimulant than methylphenidate. This effect was quickly lost, and did not come back after a considerable period of abstinence.
-undopaminergic
poster:undopaminergic
thread:1121240
URL: http://www.dr-bob.org/babble/20220917/msgs/1121381.html