Posted by SLS on July 5, 2022, at 21:39:21
In reply to Re: Celecoxib (Celebrex) for Bipolar depression?, posted by linkadge on July 5, 2022, at 18:28:38
> Yeah. You want drugs that reduce microglial inflammation, not (if possible) shutting down inflammation in the entire body.
>
> Activating the CB2 receptors is one strategy which is particularly effective for reducing microglial inflammation. Cannabis is a mish-mash of CB1 and CB2 agonists / antagonists. DHA (omega 3) produces a metabolite which is a selective CB2 agonist.
>
> Some psych meds are better at others for reducing inflammation in the brain. Nortriptyline is particularly effective. Venlafaxine is too, to a lesser extent. The SSRIs have some mild effects, but often they do not 'normalize' increased markers of inflammation in depressed patients.
>
> LinkadgeYou never fail to amaze me, Linkadge. I have been taking nortriptyline for at least 5 years. It is the most effective of all the TCAs I have tried. The only one I missed is doxepin. Somebody said that doxepin was the strongest antihistamine on the market. Is this true? Also, what do you think of using quetiapine (Seroquel) for sleep? Diphenhydramine (Benadryl) makes me feel like crap. I experience malaise on it. Would Seroquel treat me equally bad?
Thanks.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1119999
URL: http://www.dr-bob.org/babble/20220530/msgs/1120013.html