Posted by linkadge on July 5, 2022, at 18:28:38
In reply to Re: Celecoxib (Celebrex) for Bipolar depression? » Christ_empowered, posted by SLS on July 5, 2022, at 15:15:54
Yeah. You want drugs that reduce microglial inflammation, not (if possible) shutting down inflammation in the entire body.
Activating the CB2 receptors is one strategy which is particularly effective for reducing microglial inflammation. Cannabis is a mish-mash of CB1 and CB2 agonists / antagonists. DHA (omega 3) produces a metabolite which is a selective CB2 agonist.
Some psych meds are better at others for reducing inflammation in the brain. Nortriptyline is particularly effective. Venlafaxine is too, to a lesser extent. The SSRIs have some mild effects, but often they do not 'normalize' increased markers of inflammation in depressed patients.
Linkadge
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