Posted by Jay2112 on February 21, 2022, at 13:49:14
I have posted about my happiness with amphetamines, which have worked well at the same doses for going on 16 years. As well, I have to give a good nod to some tricyclics, mainly nortriptyline.
SRI's...95 percent fail. SNRI...very low dose Effexor. Ritalin...complete fail.
It seems SRI/SNRI's have had a general low success rate. On here, on med review sites like drugs.com, on Facebook groups, the RI's don't seem to make people much happier, or content, and sometimes (often?) cause even much worse behavioural and personal problems. On here...it seems like many of us have learned to get very creative, and maybe that is the key.
The RI's basically *force* the monoamine to hold in the pre-synaptic neuron. I question how healthy this mechanism is..it just seems so aggressive, compared to just making more monoamine available.
I know I am making the case simplistic, but it appears there is at least (maybe?) a grain of truth.
Sorry....just rambling..
Jay
Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-
poster:Jay2112
thread:1118711
URL: http://www.dr-bob.org/babble/20220128/msgs/1118711.html