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Re: What are the consequences of inhibiting LTP?

Posted by undopaminergic on October 6, 2021, at 11:37:52

In reply to What are the consequences of inhibiting LTP?, posted by NKP on October 6, 2021, at 4:15:09

> LTP = long-term potentiation
>
> My understanding is that LTP is the strengthening of frequently used neural pathways.
>
> Venlafaxine inhibits LTP in the hippocampus:
>
> https://pubmed.ncbi.nlm.nih.gov/19464349/
>
> What are the consequences of this? For example, would this not reduce neural plasticity?
>

I would expect learning impairment from inhibiting LTP. On the other hand, maybe it could help keep frequently used "depressive" neural pathways from getting stronger (I'm thinking especially of rumination).

-undopaminergic


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