> Should be:
>
> It is important to know that selegiline / L-deprenyl / EMSAM does not produce an antidepressant response until the dosage is high enough to inhibit MAO-A in addition to the inhibition of MAO-B at lower dosages. Selegiline is selective for MAO-B at the low dosages used to treat Parkinson's, but not at the higher dosages necessary to produce an antidepressant effect. If selegiline were *specific* for MAO-B rather than *selective*, I doubt that it would work to treat depression.
>
>
> - Scott
>
>
Hey Scott:
Great synopsis of experience/research and experimentation. I read of a few quite solid research studies on the use of a very effective combination of low dose selegiline and 5HTP in tackling dementia in Alzheimer's and Parkinson's.
I have experience with moclobemide from the past, when it first came out here in Canada. I actually did not have to modify my diet *at all*. I don't quite know why, but I (knock on wood) have never had issues with high blood pressure, and in particular, with adrenergic issues. I read that people with a particular adrenergic metabolic gene set have some difficulties with tolerating MAOIs.
But,yeah I had that on/off again effect with moclobemide. I really don't think it is good for people with major anxiety, nor bipolar.
Because I have diabetes, and problems with stomach food motility, I have been looking into some 'hacks' regarding Vagus nerve stimulation. I know it is an old issue, but there is quite a bit of research involving damage to the VN, and how that can really mess us both the brain and the rest of the body.
Thnx,
Jay
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