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Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep

Posted by undopaminergic on February 22, 2021, at 10:35:52

In reply to Re: Abilify, Vraylar, Caplyta, Zyprexa for anxiety/dep SLS, posted by undopaminergic on February 22, 2021, at 8:41:46

> >
> > I just responded to your post to me up a bit on the board. From what I've heard from psychiatrists, Latuda is the best antipsychotic weapon in the treatment of bipolar depression - even better than Abilify. The medical literature regarding lurasodone is reason for optimism.
> >
> >
> > https://pubmed.ncbi.nlm.nih.gov/?term=lurasidone+bipolar&sort=date&size=50
> >
> >
> > - Scott
>
> I've read some of the abstracts, and I found this one a bit odd:
> https://pubmed.ncbi.nlm.nih.gov/32827348/
>
> Namely, 20-60 mg of lurasidone was more effective than 80-120 mg. Should I be glad I'm not on more than 74 mg?
>
> -undopaminergic
>

This may shed some light on it:
https://sci-hub.se/https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1695777

In short: the serotonin 5-HT7-antagonism is achieved at lower doses than the dopamine D2-antagonism, and this may be responsible for the antidepressant (as opposed to the antipsychotic) effect. Meanwhile, with much higher doses, the D2-antagonism can reach levels that may produce dysphoric effects.

-undopaminergic


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