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Re: NMDA Antagonists NOT so good in psych!!

Posted by jay2112 on December 22, 2020, at 13:09:26

In reply to Re: NMDA Antagonists NOT so good in psych!!, posted by undopaminergic on December 22, 2020, at 0:54:35

> Well, I don't think it is as simple as "NMDA-antagonism = bad".
> Memantine is a NMDA-antagonist, and it is one of the most powerful antidepressants I've tried.
> Not to mention ketamine! A powerful NMDA-antagonist.
> -undopaminergic

Yes, you are right....that is like saying serotonin=happiness.

I read that partial, non-selective NDMA antagonists, seem to work quite good. Memantine, like it's 'mother', amantadine, are both partial NMDA antagonists. I think I was just getting too much antagonism.

I read that Magnesium is a strong NMDA antagonist. Calcium is the opposite, an agonist, partial. I have tried Magnesium dozens of times, and always feel like crap, afterwards. Calcium puts me to sleep. So, I am going to try another NMDA agonist, d-serine. (Which actually works good in people with schizophrenia, though I (don't think??) I don't have that...


I was brought up to believe..
Belief that's failed me now
As Life goes from bad to worse
No philosophy consoles me
In a clockwork universe..........
~Neil Peart (1952-2020)




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