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Re: Non-hallucinogenic ibogaine tested for depression linkadge

Posted by Hugh on December 18, 2020, at 11:59:31

In reply to Re: Non-hallucinogenic ibogaine tested for depression Hugh, posted by linkadge on December 11, 2020, at 19:28:24

> There is a Scottish lady who has a rare genetic variant leading to reduced FAAH expression (FAAH breaks down endocannabinoids). This leads to higher levels of endocannabinoids. She reports feeling almost no pain and no anxiety.

Metabolomic analysis reveals that recipient mice developed an altered fatty acid metabolism characterized by deficits in lipid precursors for eCBs [endocannabinoids], which resulted in impaired activity of the eCB system in the brain. Increase of the eCB levels after pharmacological blocking of the eCB degrading enzymes, or complementation of the diet with arachidonic acid (AA), a precursor of eCBs, is sufficient to alleviate both the microbiota-induced depressive-like behaviors and hippocampal neurogenesis impairments in recipient mice.

Complete article:

https://www.nature.com/articles/s41467-020-19931-2

Arachidonic acid is available from Amazon. It's popular with bodybuilders.


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