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Re: Non-hallucinogenic ibogaine tested for depression Hugh

Posted by linkadge on December 11, 2020, at 19:28:24

In reply to Re: Non-hallucinogenic ibogaine tested for depression linkadge, posted by Hugh on December 11, 2020, at 14:15:17

I wonder if the neurotrophic effect of all psychedelics can be fully replicated by a non-psychedelic. Iboga might be unique in that some of its actions are via the sigma receptors. However, I do recall reading that the neurotrophic effect of psilocybin are partially blocked by 5-h2 antagonists (which would probably also abort the psychedelic effects).

I find that certain strains of marijuanna can lift my depression, for a few days. However, for this to happen I need to get to a state where I feel a 'hyperreality'. It's hard to describe, but it is like I am in tune with a reality beyond normal and that I start to get insights (into my suffering) that are only what somebody outside myself could identify.

I also start to feel a better integration of my senses and different parts of my brain. For example, I am of the belief that depression can sometimes result from lack of communication from different regions of the brain. For example, there may be desires that are repressed, or hopelessness that needs to be challenged. Marijuana seems to help me confront my fears in a way that is not overwhelming. Like I can process ('see') the fears and reframe them in a more positive light.

Sometimes when I get depressed, I feel completely overwhelmed, and my brain shuts down to avoid having to process painful thoughts. It feels like weed is opening a window, where I can see the negative thoughts, and process them without feeling them.

There is a Scottish lady who has a rare genetic variant leading to reduced FAAH expression (FAAH breaks down endocannabinoids). This leads to higher levels of endocannabinoids. She reports feeling almost no pain and no anxiety.

Linkadge


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