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Re: Suggestions on treating Tardive Dyskinesia TD? jay2112

Posted by undopaminergic on November 7, 2020, at 3:22:33

In reply to Re: Suggestions on treating Tardive Dyskinesia TD?, posted by jay2112 on November 6, 2020, at 17:09:40

> > > Propranolol, Amantadine, and clonidine.
> >
> > Amantadine sounds interesting. I would be concerned that clonidine would cause depression.
> >
> >
> > - Scott
>
> I found amantadine to have a good antidepressant quality. Not as robust as the standard stimulants, but works well in a mix with antidepressants and a stimulant. May work well against t.d. I actually found amphetamine to be a good med to fight t.d. (Even though it is a suspected cause.) Yes, clonidine does have that depression-inducing quality, but in small doses, I found it useful for akathisia. That is the most intolerable aspect of EP symptoms, for me, anyway.
>
> I was also thinking, amitriptyline has a strong anti-cholinergic profile, which may be also effective for depression. But, treatment response vs. side effects. Hmmmm..
>

Amantadine can also augment antidepressants in animal models of depression.

It may have been the trigger for an intense hypomanic episode I had in late 2007 to early 2008.

Memantine can be a stronger alternative to amantadine. Structurally, these agents are very similar; memantine is dimethyl-amantadine.

-undopaminergic


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