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Re: New Study:Females have more Adverse Drug Reactions

Posted by Mtom on October 19, 2020, at 9:54:50

In reply to Re: New Study:Females have more Adverse Drug Reactions, posted by undopaminergic on October 19, 2020, at 3:55:23

I am the last person to want to sexualize anything. And I agree that "personalized medicine" is the way of the future although have doubts it will happen anytime soon. There are of course many differences between individuals that include not just weight and the other factors discussed in these papers, but also genetics, comorbidities, taking multiple drugs, diet, etc. that may impact both efficacy and adverse drug reactions (ADRs).

However I'm just reading and commenting on what the researchers found in this particular scientific paper. The researchers state that females have almost 2 x more adverse effects than males. They found differences in the ways females absorb, distribute, metabolize and eliminate drugs etc., (i.e. pharmacokinetics, detailed in the linked paper).

The paper notes - I'm paraphrasing - that females are (on average) smaller than males and generally a lower proportion of muscle mass yet they say that some evidence shows adjusting for weight differences does not always reduce the number of ADRs in females. They do quote both one paper which argues that body weight "is" the factor as well as another which found this "not" to be the case. Their own analysis also finds differences in ADRs remain after correcting for body weight. They also note that more intensive research is needed.

The paper is interesting, discusses in much more detail than I can post all the factors that may play a role, and is really worth a read.

They finish with notes that include the observation that most basic research is conducted in male animals, whether cell lines or in vivo and various recommendations including that drugs when feasible should be dosed on a body weight bases for "both" men and women as well as other recommendations.

> Doses need to be individualised, not sexualised. That said, it may make sense to use a lower starting dose for women, as they do for children and the elderly.
> -undopaminergic




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