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Females higher blood conc..., longer elimination

Posted by Mtom on October 18, 2020, at 11:36:23

In reply to New Study:Females have more Adverse Drug Reactions, posted by Mtom on October 18, 2020, at 11:31:15

Gender is generally not revealed in posts, however this study suggests it to be one factor in differences between side effects among patients.

> A study published in June 2020 from researchers at the University of California Berkeley and the University of Chicago found that Women have a nearly 2-fold greater risk than men for
> exhibiting ADRs across all drug classes and are significantly more likely to be hospitalized secondary to an Adverse Drug Reaction. This included antidepressant drugs (see list of drugs investigated in article linked below). They discuss that Pharmacokinetics differ between males and females. They also note that most drugs are not administered on a milligram/kilogram basis but as a one size fits all dose, leading to higher exposures in women and optimally dose should be based on mg/kg body weight However corrections for height, weight and body composition eliminates only a minority of gender dependent pharmacokinetic differences.
> In the discussion they note their results show a striking sex difference in pharmacokinetics: among patients administered a standard drug dose, females are exposed to higher blood drug concentrations and longer drug elimination times than males. This likely contributes to the near doubling of adverse drug reactions in female patients, raising the possibility that women are routinely overmedicated.
> Sex differences in pharmacokinetics predict adverse drug reactions in women Irving Zucker1,2* and Brian J. Prendergast
> Another interesting 2016 paper on this topic Sex differences in the psychopharmacological treatment of depression can be downloaded through
> It would be interesting to hear Dr. Bob's thoughts on this.....




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