Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Akathisia, meds , Pseudo-Parkinson and help pls.:( linkadge

Posted by jay2112 on October 17, 2020, at 17:21:47

In reply to Re: Akathisia, meds , Pseudo-Parkinson and help pls.:(, posted by linkadge on October 17, 2020, at 15:38:10

Thanks Linkadge. Yep, I have tried most antipsychotics..typical and atypical. Abilify was the most wretched experience...it's like the agonism and antagonism are playing tug-of-war in the brain.
And the akathisia was the absolute worst..like a form of human torture. (For me, anyways.) Latuda is definitely the best one I have been on. That prison of ice-cold fear, of even my own shadow, has for the first time in a few decades, brought me back to a kinder, gentler reality.

I just wanted to underscore that my neurologist felt my symptoms were pseudo parkinson's, quite possibly from a few of my meds, as he has had quite a few similar cases. So, it's not a Parkinson's diagnosis, just the possibility we might have to change up a med or two, and observe over the long term. My aunt and my great-grandmother both had Parkinson's. He said we won't touch the Latuda, as I said, it brought me back to reality. He was a bit concerned about the antidepressants, and my former use of stimulants, may have slightly altered both my serotogenic and dopamine pathways.(He did not make a co-relation, directly, though, as he said psych meds, at therapeutic doses used, are actually neuro-protective.) I have had a few MRI's and CAT scans, and he said previously that "..all seems fine under the hood." LOL. I have tried almost every psych med out there.

I am on Latuda, Effexor, clonazepam, Lamictal, 25 mg of Remeron at bed, and .5mg of risperidone as a PRN. Interesting thing about Effexor...he said there is a bit of a controversy on it's effects on norepinephrine, that it is a fair bit weaker on norepinephrine than thought...even with the dose escalation.(I'd have to look up the references.)

So, we may try an anti-cholinergic (but no additional antidepressants, till we figure this out.) and a small dose of a dopamine agonist..but we will decide when we meet next week. He is just afraid of the psychosis.

And, I tried CBD, a few times, and it was just like a placebo. Surprisingly, cannabis is hit and miss, but I don't want to chance psychosis. One med that works *really* well is Lyrica..even way better than benzo's for for anxiety, and help's with depression too. But, I developed tolerance, and maxed it right out. Same with gabapentin.

So, that is where I am at. The Latuda was a huge game-changer for me. Seroquel, which also acts as a weak partial dopamine agonist, and Zyprexa (which I maxed out) really bring on heavy, heavy depression, me being BP2. Zyprexa almost made me OCD...I think because of antagonism at one of the serotonin receptors.

One thing I really don't understand in the research, is that they should try more specific-site serotonin receptors, combined with adrenal blockage...or more specific norepinephrine antagonists. It seems like clozapine does a lot of this, and about the agranulocytosis risk, it being only about 1 percent, and in some European countries, is only test for monthly, after being on the med for awhile.


I was brought up to believe..
Belief that's failed me now
As Life goes from bad to worse
No philosophy consoles me
In a clockwork universe..........
~Neil Peart (1952-2020)


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:jay2112 thread:1112287
URL: http://www.dr-bob.org/babble/20200711/msgs/1112292.html