Posted by linkadge on August 19, 2020, at 12:42:32
In reply to Caplyta (lumateperone) - Reduces glutamate., posted by SLS on August 18, 2020, at 22:25:18
Looking at the wikipedia article, it almost seems to be a selective 5-ht2a antagonist:
5-HT2A0.54
Dopamine receptor D141
Serotonin transporter33
Dopamine receptor D232
Dopamine receptor D4<100
Alpha-1A adrenergic receptor<100
Alpha-1B adrenergic receptor<100
There was another selective 5-ht2 antagonist (pimavanserin) released recently for Parkinson's releated hallucinations. Interestingly blocking 5-ht2a produces downstream effects on GSK3, which then in turn modulates D2 receptor sensitivity. In some models selective 5-ht2a antagonists are antipsychotic.Linkadge
poster:linkadge
thread:1111767
URL: http://www.dr-bob.org/babble/20200711/msgs/1111771.html