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Re: Caplyta (lumateperone) - Reduces glutamate.

Posted by linkadge on August 19, 2020, at 12:42:32

In reply to Caplyta (lumateperone) - Reduces glutamate., posted by SLS on August 18, 2020, at 22:25:18

Looking at the wikipedia article, it almost seems to be a selective 5-ht2a antagonist:

Dopamine receptor D141
Serotonin transporter33
Dopamine receptor D232
Dopamine receptor D4<100
Alpha-1A adrenergic receptor<100
Alpha-1B adrenergic receptor<100

There was another selective 5-ht2 antagonist (pimavanserin) released recently for Parkinson's releated hallucinations. Interestingly blocking 5-ht2a produces downstream effects on GSK3, which then in turn modulates D2 receptor sensitivity. In some models selective 5-ht2a antagonists are antipsychotic.





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