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Caplyta (lumateperone) - Reduces glutamate.

Posted by SLS on August 18, 2020, at 22:25:18

Someone asked me if I knew of any glutamate release inhibitors. The first drug to pop into my head was lamotrigine. However, the new "antipsychotic", Caplyta (lumateperone), works to lower glutamate activity secondary to its agonism of D1 receptors. Lumateperone is also a potent 5-HT2a receptor antagonist, but has low affintiy for D2 receptors.

Glutamatergic neurotransmission isn't the easiest to figure out. Sometimes it makes more sense to look at what brain structures or neural tracts are activated or inhibited by exposure to a drug. It might be a good idea to follow lumateperone to see if it has any utility in unipolar or bipolar disorders.

The reason I put "antipsychotic" in quotes is because a chemical compound doesn't always know what it's supposed to be.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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