Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: I can't take much more! Anxiety overwhelming! SLS

Posted by Englishman006! on August 15, 2020, at 20:59:32

In reply to Re: I can't take much more! Anxiety overwhelming!, posted by SLS on August 15, 2020, at 19:28:00

> > > > I have found that there are unacceptable differences in the clinical effects of different brands of lamotrigine. Something should be done about it. To the best of my knowledge, no other anticonvulsant is so variable in its therapeutic effects. I have to jump through some hoops, but I use the Lamictal brand. Mylan lamotrigine was the worst. Teva lamotrigine was the best until they discontinued it and then resumed supplying it. All of their versions are now XR extended release. Obviously this isn't the same product they sold previously. My guess is that the drug is manufactured by the company they acquired, who was already making it. The first XR sold by Teva sucked, from what I understand. Still, it might be worth a try.
> > > >
> > > > If anyone feels that their generic lamotrigine works as well as the original Lamictal, please share your observations. Generic company and dosages would be great information.
> > > >
> > > >
> > > > - Scott
> > >
> > > I have been on different brands of Lamotrigine and you're right, there is an extreme difference. I too take Lamictal. I've also reacted badly to dexamphetamine when it was made into extended release, high dose, by a compounding pharmacy. I think new xr versions or brands of any med should be taken with caution...
> > >
> > > Lamotrigine also gives me bad melasma, a side effect not mentioned in any of the literature I've read. I think I may be the odd one out on that skin pigmentation disorder. There doesn't seem to be an alternative glutamate blocker in its class, so I'm stuck with it.
> >
> > I think you're right about glutamate inhibitors and depression. Valproate is pretty good at reducing glutamate activity through the inhibition of GABA transaminase, and possibly through the blocking of sodium channels upstream.
>
> Calcium channels, too.
>
>
> - Scott

Valproate, what do you think of this drug overall, including side effect profile? I would be extremely interested in getting rid of my melasma. Lamotrigine has been a god send as it gave me back my 'talking tackle' after the dexamphetamine+ memantine combo kind of pooped out in that regard.

I also get extreme fatigue but put up with it in order to have a sense of wit and humour. Coffee adds to it but stimulates me mentally. It's such a rough and juggle thing with meds don't you think?


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Englishman006! thread:1111554
URL: http://www.dr-bob.org/babble/20200711/msgs/1111699.html