Posted by linkadge on July 25, 2020, at 17:47:31
In reply to Re: Dopa-responsive Dystonia, posted by pixel8mbb on July 25, 2020, at 14:50:44
Interesting. I'll try and read a bit more on this issue to be better informed. The reason I am intrigued is that often psychiatric disorders just get chalked up to personality. Its nice to have something on paper that says "no - my brain does, in fact work differently, fundamentally"
Yes, having a low acting version of COMT would prolong the effects of dopamine. Given that you have reduced BH4, this might offset the dopamine deficit to some degree. COMT inhibitors can be used to prolong the effects of dopa. As far as novelty seeking, was this in the dopamine D4 gene that was analyzed? Interestingly, rTMS does have a pretty significant effect on dopamine.
Have you ever tried marijuanna? I remember reading that low COMT was associated with more adverse reactions, but this may be offset (in your case) by lower dopamine synthesis.
>depression, anxiety, OCD, and trouble sleeping
Sounds like me (of course, I have taken no tests to guide me). Tack on the ADD issues and we have similar symptoms. I have not really responded well to many psych meds. I'm currently on venlafaxine, mirtazapine, atomoxetine and lithium, but I relapse frequently. I also take medical marihuana, as needed.
Keep us informed about what / if is helping.
Linkadge
poster:linkadge
thread:1111348
URL: http://www.dr-bob.org/babble/20200711/msgs/1111388.html