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Re: COMT gene

Posted by undopaminergic on June 27, 2020, at 1:25:14

In reply to Re: COMT gene, posted by linkadge on June 26, 2020, at 18:53:17

> Entacapone (a COMT inhibitor) is used in Parkinson's to increase the effects of L-dopa.

Entacapone is not centrally active. There is another one, tolcapone, that does cross the BBB. It has been evaluated for depression in some studies. It has some liver toxicity issues, but you can do liver function monitoring.

I've also read that green tea catechins can inhibit COMT.





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