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Re: How does Lumateperone compare to antidepressants?

Posted by undopaminergic on June 23, 2020, at 21:32:29

In reply to Re: How does Lumateperone compare to antidepressants?, posted by linkadge on June 23, 2020, at 18:07:32

> Lumateperone is a very strong antagonist of 5-ht2a and much less potent as an antagonist at dopamine receptors.
> If it is combined with an SSRI, there is a very very low possibility of some degree of serotonin syndrome.

Why's that? You say it's a very strong serotonin 5-HT2A receptor antagonist, so if anything, I would expect it to be an *antidote* to serotonin syndrome.





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