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Re: How does Lumateperone compare to antidepressants? undopaminergic

Posted by linkadge on June 24, 2020, at 7:35:54

In reply to Re: How does Lumateperone compare to antidepressants?, posted by undopaminergic on June 23, 2020, at 21:32:29

From what I understand, over-activation of the 5-ht1a receptor is part of the process mediating serotonin syndrome (both 5-ht1a and 5-ht2a mediate different aspects of serotonin syndrome). When you block one serotonin receptor, this leaves more serotonin to activate other receptors (i.e. 5-ht1a).

Again, I said the risk was very very low, but there have been case reports of serotonin syndrome when adding atypical antipsychotics to SSRIs.

For example:

https://pubmed.ncbi.nlm.nih.gov/12639169/

(although there is some overlap between the symptoms of serotonin syndrome and neuroleptic malignant syndrome).

Linkadge


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