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Re: Nardil(MAO) plus high dose stimulant/ Anyone?

Posted by undopaminergic on June 17, 2020, at 3:54:57

In reply to Nardil(MAO) plus high dose stimulant/ Anyone?, posted by Stargazer2 on June 16, 2020, at 18:12:03

> So how do you explain what I went through?

I didn't mean your experience was *not* due to the MAOI + Ritalin. It probably was, because it is temporally linked to the 10 mg Ritalin you added.

> Have you ever had the hypertensive crisis related to a MAO and Ritalin?

The only MAOIs I've taken are selegiline and rasagiline, and that probably doesn't count.

> I would like to hear of all the others taking high dose stimulants plus a MAO and hear how many had reactions. I would not think there are many.

I can't actually recall anyone (else) who reported a serious hypertensive reaction with a stimulant. That is why I think it is rare.

The relevant mechanism of action of Ritalin in this context is the noradrenaline reuptake inhibition, which is shared with a number of non-stimulant drugs. Ken Gillman, a MAOI expert, suggests that TCAs without serotonin reuptake inhibitory effects are safe to combine with MAOIs.

I did have mixed experience with selegiline + reboxetine. It was in part unpleasant, but I did not measure my blood pressure.

> As far as food goes yes you may not always have the reaction eating certain foods but can you say confidently you never will.

Of course not. The dietary restrictions were introduced because some people had serious reactions, some of which were fatal.

According to Gillman, there are very few foods today containing enough tyramine to trigger a serious reaction. That's probably the reason why you (nowadays) get away with ignoring the MAOI diet.

> I think this is one reason doctors will never order MAOs to anyone that doesnt have the ability to understand certain foods or drugs could kill you.


> What if I wasnt able to take my pressure or take the drug I did to lower my BP? Most would not have done what I did and the outcome could have been a stroke.

I'm not saying you did not have a serious reaction.





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