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Re: Clomipramin, Tryptophan and Lithium in Combination undopaminergic

Posted by Skeletor on June 7, 2020, at 11:00:15

In reply to Re: Clomipramin, Tryptophan and Lithium in Combination, posted by undopaminergic on June 7, 2020, at 9:15:57

> > Hey,
> >
> > You could always through an MAOI into the mix for added serotonin greatness (kidding - DON'T DO THIS).
> >
> "Throwing" a MAOI into the mix would be irresponsible and reckless, but the dose always makes the poison. If you need this combination, which is improbable but not unthinkable, you should start with the MAOI and reach a steady dose, then carefully introduce the precursor or the (S)SRI. Liquid preparations of SSRIs would be particularly appropriate for this purpose.
> -undopaminergic

Better idea: add Amitriptyline. It doesn't seem to cause Serotonin syndrome when added to MAOI. It maybe can reach 70 - 80% SERT occupation at high doses, but it is a very strong 5HT2 antagonist and that might attenuate serotonin toxicity in combination with MAOI.




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