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Re: Mechanism of Sleep Deprivation in Depression Jadde

Posted by linkadge on May 18, 2020, at 10:42:23

In reply to Re: Mechanism of Sleep Deprivation in Depression linkadge, posted by Jadde on May 18, 2020, at 10:34:14

>I was euphoric for a full day following a night of >no sleep. Its tempting.

After reading on the mechanism (adenosine increase) I looked for other agents which can increase adenosine. All I could find were magnesium, pot and valerian root. Valerian is an A1 adenosine agonist and magnesium (although it doesn't raise adenosine on its own) is required for the synaptic actions of adenosine (i.e magnifying the effects). Pot increases adenosine via activation of the cb1 receptors. I do get a mood improvement with marijuana and magnesium seems to potentiate the effect. I wonder if marijuanna could potentiate the effects of sleep deprivation on depression.





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