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Re: Mechanism of Sleep Deprivation in Depression linkadge

Posted by undopaminergic on May 18, 2020, at 9:03:55

In reply to Re: Mechanism of Sleep Deprivation in Depression undopaminergic, posted by linkadge on May 18, 2020, at 8:15:26

> Caffeine could possibly produce depression in some individuals. I do get a perk from sleep deprivation and it seems that drinking coffee the next morning seems to bring my mood down a bit. But at other times, it can improve my mood.
> That being said, A1 antagonists (including caffeine) do produce antidepressant effects in some animal models. Also, A2 antagonists (including caffeine) produce neuroprotective effects and may reduce the risk of parkinsons.
> Linakdge

I find that (1) I get little effect either way from caffeine alone, but (2) taken with a cocaine-like stimulant (in my case desoxypipradrol or ethylphenidate) it provides an excellent nootropic boost. I have tried up to 3000 mg of caffeine alone, without any notable benefits, but the worst night of my life due to stomach pains. Whence the complete contrast between (1) and (2)?





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