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Re: AP's and relief

Posted by undopaminergic on March 25, 2020, at 4:47:32

In reply to Re: AP's and relief, posted by Lamdage22 on March 25, 2020, at 3:06:53

> Hi undopaminergic,


> i am trying to avoid tardive dyskinesia and Sulprid or Amisulpride is notorious for that. And the reviews of Tiapride are not the best.

I don't agree tardive dyskinesia (TD) is at all common with sulpiride or amisulpride. In fact it is rare even with the old typicals.

This is an interesting report on TD with quetiapine (Seroquel):
It is particularly interesting because there was no TD with amisulpride but after switching to quetiapine it manifested, and the TD worsened after switching to ziprasidone. All of these drugs are atypical APs.

There are obviously individual vulnerabilities at play here. TD cannot be predicted, and it seems that it can happen with any AP, including clozapine:
In this study, the patient developed TD after more than 6 years of clozapine. It does not make intuitive sense.

> I can live with the side effects. I can't live with tardive dyskinesia and disfigurement because of tics.

I agree it would be most unfortunate. That is another reason to minimise exposure to APs.

> Long term I am planning to come off of Seroquel. I just reduced it from 800 to 700.

Oh, I'm glad to hear that. Your signature still says 900 mg.

> Sometimes doing nothing with meds is better. Or do you find that the "trymania" here leads to success very often?

Most suggestions made here are not implemented, and in most cases, the individual is lost to follow-up. I don't think the success rate of suggestions here are worse than the trials done by psychiatrists, but quite possibly better.





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