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Re: AP's and relief

Posted by undopaminergic on March 23, 2020, at 5:31:40

In reply to Re: AP's and relief, posted by Lamdage22 on March 23, 2020, at 0:21:14

> For the most part, yes. I think it helps me think more clearly. I'm not as prone to believing fake news and conspiracy theories. But it is kind of last resort. The side effects are not mild.
>

In general, the most notable effect I get is the sedation from histamine antagonism.

Clozapine is regarded as the best anti-psychotic (AP) but it does very little for me, other than make me drool on the pillow at night, because it disrupts the swallowing reflex, and makes me choke on some kinds of food unless I wash it down with milk or other liquid.

Trimipramine (Surmontil) which I started taking for depression, is the most potent AP for me so far. After I started it, I've come to the insight that it is very important to avoid manic episodes. I have also gained some insight into why I've ended up in hospital repeatedly -- I'm not just a victim of circumstance or other people. Trimipramine has a receptor binding profile that resembles clozapine, so its more potent AP-like effects are a curious thing.

What are your notable side-effects?

-undopaminergic


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