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What has been the best SSRI for you?

Posted by Skeletor on March 11, 2020, at 8:35:42

I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.

From all the SSRIs that you've taken, which one has been "the best"?

Here a list with all the SSRIs:


We can also count in the following drugs:

Venlafaxine (Effexor)
Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Vilazodone (Viibryd)
Vortioxetine (Trintellix)

Although described as SNRIs, duloxetine (Cymbalta), venlafaxine (Effexor), and desvenlafaxine (Pristiq) are in fact relatively selective as serotonin reuptake inhibitors (SRIs).[130] They are about at least 10-fold selective for inhibition of serotonin reuptake over norepinephrine reuptake.[130] The selectivity ratios are approximately 1:30 for venlafaxine, 1:9 for duloxetine, and 1:14 for desvenlafaxine.[130] At low doses, these SNRIs act mostly as SSRIs

Vilazodone (Viibryd) and vortioxetine (Trintellix) are SRIs that also act as modulators of serotonin receptors and are described as serotonin modulators and stimulators (SMS).[134] Vilazodone is a 5-HT1A receptor partial agonist while vortioxetine is a 5-HT1A receptor agonist and 5-HT3 and 5-HT7 receptor antagonist.





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