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Re: Anticholinergics as antidepressants undopaminergic

Posted by linkadge on December 27, 2019, at 17:11:02

In reply to Anticholinergics as antidepressants, posted by undopaminergic on December 27, 2019, at 11:15:45

Anticholinergics can be antidepressants. Benztropine can be abused (euphorogenic effects). Benztropine is also a dopamine reuptake inhibitor as well as anticholinergic. I purchased some belladonna extract. You've got to be careful...one single drop can be felt!

I would say that the anticholinergic effects of TCAs add to their antidepressant effects. They can also reduce side effects (i.e. akathisia). Trimipramine is also a 5-ht2 antagonist which can have antidepressant effects. Some of its metabolites have some impact on DAT and MAO-B.

There may be some additional (yet unidentified) mechanism common to the TCAs (I.e. anti-inflammatory, or epigenetic). Trimipamine likely has anticortisol effects and may affect HPA axis at a more fundamental level. Trimipramine elevates the expression of D2 and D3 receptors (common to many antidepressants, but not mirtazapine). I believe it interacts with opioid systems like other TCAs.

Linkadge


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