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Anticholinergics as antidepressants

Posted by undopaminergic on December 27, 2019, at 11:15:45

Hi all,

I have known for years that scopolamine has antidepressant effects in many people; see for example:
(free full article available.)

I am wondering if other anticholinergics (aka. antimuscarinics), such as atropine, have similar effects. Euphoria is specifically reported as a side effect of orphenadrine.

Is the anticholinergic action of other drugs, such as most tricyclic antidepressants (TCAs), an important mechanism behind their antidepressant action?

The TCA I'm on, trimipramine, does not inhibit the reuptake of any monoamine neurotransmitters, but is reportedly equally effective to other antidepressants. It was found more effective than MAOIs in one study. I'm wondering if the reason for this may be its anticholinergic action.





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