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Re: is rexulti a viable option? Christ_empowered

Posted by undopaminergic on December 17, 2019, at 11:18:20

In reply to is rexulti a viable option?, posted by Christ_empowered on December 11, 2019, at 18:57:13

From what I've read, cariprazine (Reagila here; what you call Vraylar) is the most activating of the dopamine partial agonist-antipsychotics. I'm currently taking it, and I like it better than aripiprazole (Abilify), but to be fair, I took a high dose of Abilify and I'm only on 3 mg of cariprazine.

The unique feature of cariprazine, is that it has a preference for dopamine D3-receptors. Whether that is good or bad, I'm not sure. However, pramipexole (Sifrol), a dopamine D3/D2 receptor direct agonist, was the only drug that was anti-anhedonic for me. I can at least say cariprazine is nothing of the sort. At higher doses, it acts more as an antagonist, which would be a bad thing in the case of D3.





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