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Re: low dopamine linked to addiction

Posted by undopaminergic on December 2, 2019, at 11:07:37

In reply to Re: low dopamine linked to addiction rjlockhart37, posted by jay2112 on December 1, 2019, at 12:39:39

> To note, I was on Suboxone, and it made me feel horrible. Being a positive opioid user, you'd think it would have helped. I found that very strange. I think the naltrexone in it, that push and pull of opioid antagonism and agonism, has a very jarring effect.
>

Naloxone, not naltrexone. It is supposed to not be absorbed sublingually, unlike the buprenorphine. The problem you had was probably with the buprenorphine itself. It is a strange opioid, with partial agonism at mu-opioid receptors, and antagonism at kappa-opioid receptors. It had no painkilling effects whatsoever for me, but (at least in combination with methylphenidate) it really helped my working memory and attention. It was the best combination I've ever been on. At first, I got mild euphoria from the mu-agonism, but I think the kappa-antagonism was the most important for me. It was mainly a nootropic for me.

Then I got deprived of both of these medications and my life was turned upside down again, as I plunged back into apathy.

Buprenorphine binds very tightly to the mu-receptors and so, it blocks the effects of other opioids taken at the same time. This is one of the main reasons it is used to treat addiction.

As for low dopamine driving people to addiction, it is true. You may think of it as being dependent on stimulants before you have taken any.

-undopaminergic


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