Posted by SLS on July 23, 2019, at 7:26:38
In reply to Re: Can antidepressants work quickly?, posted by porkpiehat on July 22, 2019, at 14:15:24
> If I understand correctly, a lot of AD's can spike a neurotransmitter or block/agonize a receptor immediately...then the brain down or upregulates something else in the follow couple of weeks where the "true" AD effect supposedly lies.
>
> I would think there would be some diagnostic value in responding better to the initial action vs the later state. I know this happens to me a lot.All of your thoughts make sense, and I have tended to embrace them in the past. Now, I also look at the immediate effect of ketamine and the role that BDNF and inflammation might play in the latency of response to antidepressants. Somewhere, there must be a balance between the adages, "the more we learn, the more we realize how little we understand" and "keep it simple, stupid".
I don't know nearly as much now as I did 20 years ago.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1105281
URL: http://www.dr-bob.org/babble/20190513/msgs/1105376.html